研究業績｜筑波大学国際統合睡眠医科学研究機構櫻井/平野研究室

ORIGINAL RESEARCH

Functional Roles of Gastrin-Releasing Peptide-Producing Neurons in the Suprachiasmatic Nucleus: Insights into Photic Entrainment and Circadian Regulation

Li R, Inoue R, Mori H, Hirano A, Sakurai T.

J Neurosci. 2025 Jun 18;45(25):e0065252025. doi: 10.1523/JNEUROSCI.0065-25.2025.

ORIGINAL RESEARCH

Sequential transitions of male sexual behaviors driven by dual acetylcholine-dopamine dynamics

Miyasaka A, Kanda T, Nonaka N, Terakoshi Y, Cherasse Y, Ishikawa Y, Li Y, Takizawa H, Hirano A, Seita J, Yanagisawa M, Sakurai T, Sakurai K, Liu Q.

Neuron. 2025 Apr 16;113(8):1240-1258.e10. doi: 10.1016/j.neuron.2025.01.032. Epub 2025 Mar 19.

ORIGINAL RESEARCH

Parameterized resetting model captures dose-dependent entrainment of the mouse circadian clock

Masuda K, Yoshimoto R, Li R, Sakurai T, Hirano A.

Nat Commun. 2025 Feb 6;16(1):1421. doi: 10.1038/s41467-025-56792-z.

ORIGINAL RESEARCH

Utility of complexity analysis in electroencephalography and electromyography for automated classification of sleep-wake states in mice

Furutani N, Saito YC, Niwa Y, Katsuyama Y, Nariya Y, Kikuchi M, Takahashi T, Sakurai T.

Sci Rep. 2025 Jan 24;15(1):3080. doi: 10.1038/s41598-024-74008-0.

ORIGINAL RESEARCH

Central amygdala NPBWR1 neurons facilitate social novelty seeking and new social interactions

Soya S, Toda K, Sakurai K, Cherasse Y, Saito YC, Abe M, Sakimura K, Sakurai T.

Sci Adv. 2025 Jan 17;11(3):eadn1335. doi: 10.1126/sciadv.adn1335. Epub 2025 Jan 15.

ORIGINAL RESEARCH

A coupled model between circadian, cell-cycle, and redox rhythms reveals their regulation of oxidative stress

Masuda K, Sakurai T, Hirano A.

Sci Rep. 2024 Jul 5;14(1):15479. doi: 10.1038/s41598-024-66347-9.

ORIGINAL RESEARCH

Regulation of REM sleep in mice: The role of dopamine and serotonin function in the basolateral amygdala

Hasegawa E, Li Y, Sakurai T.

Neurosci Res. 2024 Mar;200:28-33. doi: 10.1016/j.neures.2023.09.003. Epub 2023 Sep 9.

ORIGINAL RESEARCH

Aripiprazole disrupts cellular synchrony in the suprachiasmatic nucleus and enhances entrainment to environmental light-dark cycles in mice.

Li R, Masuda K, Ono D, Kanbayashi T, Hirano A, Sakurai T.

Front Neurosci. 2023 Aug 9;17:1201137. doi: 10.3389/fnins.2023.1201137. PMID: 37621713; PMCID: PMC10445652.

ORIGINAL RESEARCH

Measuring body temperature of freely moving mice under an optogenetics-induced long-term hypothermic state

Takahashi TM, Sakurai T, Hirano A.

STAR Protoc. 2023 May 31;4(2):102321. doi: 10.1016/j.xpro.2023.102321.

ORIGINAL RESEARCH

Structure and Function of Neuronal Circuits Linking Ventrolateral Preoptic Nucleus and Lateral Hypothalamic Area

Prokofeva K, Saito YC, Niwa Y, Mizuno S, Takahashi S, Hirano A, Sakurai T.

J Neurosci. 2023 May 31;43(22):4075-4092. doi: 10.1523/JNEUROSCI.1913-22.2023. Epub 2023 Apr 28.

ORIGINAL RESEARCH

Singularity response reveals entrainment properties in mammalian circadian clock.

Masuda K, Kon N, Iizuka K, Fukada Y, Sakurai T, Hirano A.

Nat Commun. 2023 May 17;14(1):2819. doi: 10.1038/s41467-023-38392-x.

ORIGINAL RESEARCH

Analysis of circadian rhythm components in EEG/EMG data of aged mice

Masuda K, Katsuda Y, Niwa Y, Sakurai T, Hirano A.

Front Neurosci. 2023 May 12;17:1173537. doi: 10.3389/fnins.2023.1173537.

ORIGINAL RESEARCH

Optogenetic induction of hibernation-like state with modified human Opsin4 in mice.

Takahashi TM, Hirano A, Kanda T, Saito VM, Ashitomi H, Tanaka KZ, Yokoshiki Y, Masuda K, Yanagisawa M, Vogt KE, Tokuda T, Sakurai T.

Cell Rep Methods. 2022 Nov 14;2(11):100336. doi: 10.1016/j.crmeth.2022.100336. PMID: 36452866; PMCID: PMC9701604.

ORIGINAL RESEARCH

Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice

Emi Hasegawa, Ai Miyasaka, Katsuyasu Sakurai, Yoan Cherasse, Yulong Li, Takeshi Sakurai

Science . 2022 Mar 4;375(6584):994-1000. doi: 10.1126/science.abl6618. Epub 2022 Mar 3.

ORIGINAL RESEARCH

A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice

Uchida S, Soya S, Saito YC, Hirano A, Koga K, Tsuda M, Abe M, Sakimura K, Sakurai T.

Journal of Neuroscience 17 February 2021, 41 (7) 1582-1596; DOI: https://doi.org/10.1523/JNEUROSCI.0688-20.2020

ORIGINAL RESEARCH

Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β

Nakai A, Fujiyama T, Nagata N, Kashiwagi M, Ikkyu A, Takagi M, Tatsuzawa C, Tanaka K, Kakizaki M, Kanuka M, Kawano T, Mizuno S, Sugiyama F, Takahashi S, Funato H, Sakurai T, Yanagisawa M, Hayashi Y.

Genetics. 2020 Nov;216(3):753-764. doi: 10.1534/genetics.120.303435. Epub 2020 Sep 2.

ORIGINAL RESEARCH

A discrete neuronal circuit induces a hibernation-like state in rodents

Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T.

Nature. 2020 Jul;583(7814):109-114. doi: 10.1038/s41586-020-2163-6. Epub 2020 Jun 11.

ORIGINAL RESEARCH

Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation

Kumar D, Koyanagi I, Carrier-Ruiz A, Vergara P, Srinivasan S, Sugaya Y, Kasuya M, Yu TS, Vogt KE, Muratani M, Ohnishi T, Singh S, Teixeira CM, Chérasse Y, Naoi T, Wang SH, Nondhalee P, Osman BAH, Kaneko N, Sawamoto K, Kernie SG, Sakurai T, McHugh TJ, Kano M, Yanagisawa M, Sakaguchi M.

Neuron. 2020 Aug 5;107(3):552-565.e10. doi: 10.1016/j.neuron.2020.05.008. Epub 2020 Jun 4.

ORIGINAL RESEARCH

Narcolepsy – clinical spectrum, aetiopathophysiology, diagnosis and treatment

Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U, Khatami R, Koning F, Kornum BR, Lammers GJ, Liblau RS, Luppi PH, Mayer G, Pollmächer T, Sakurai T, Sallusto F, Scammell TE, Tafti M, Dauvilliers Y.

Nat Rev Neurol. 2019 Sep;15(9):519-539. doi: 10.1038/s41582-019-0226-9. Epub 2019 Jul 19.

ORIGINAL RESEARCH

Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice

Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K, Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K.

Addict Biol. 2020 Jan;25(1):e12723. doi: 10.1111/adb.12723. Epub 2019 Feb 7.

PUBLICATIONS研究業績

Functional Roles of Gastrin-Releasing Peptide-Producing Neurons in the Suprachiasmatic Nucleus: Insights into Photic Entrainment and Circadian Regulation

Sequential transitions of male sexual behaviors driven by dual acetylcholine-dopamine dynamics

Parameterized resetting model captures dose-dependent entrainment of the mouse circadian clock

Utility of complexity analysis in electroencephalography and electromyography for automated classification of sleep-wake states in mice

Central amygdala NPBWR1 neurons facilitate social novelty seeking and new social interactions

A coupled model between circadian, cell-cycle, and redox rhythms reveals their regulation of oxidative stress

Regulation of REM sleep in mice: The role of dopamine and serotonin function in the basolateral amygdala

Aripiprazole disrupts cellular synchrony in the suprachiasmatic nucleus and enhances entrainment to environmental light-dark cycles in mice.

Measuring body temperature of freely moving mice under an optogenetics-induced long-term hypothermic state

Structure and Function of Neuronal Circuits Linking Ventrolateral Preoptic Nucleus and Lateral Hypothalamic Area

Singularity response reveals entrainment properties in mammalian circadian clock.

Analysis of circadian rhythm components in EEG/EMG data of aged mice

Optogenetic induction of hibernation-like state with modified human Opsin4 in mice.

Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice

A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice

Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β

A discrete neuronal circuit induces a hibernation-like state in rodents

Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation

Narcolepsy – clinical spectrum, aetiopathophysiology, diagnosis and treatment

Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice