研究業績｜筑波大学国際統合睡眠医科学研究機構櫻井/平野研究室

ORIGINAL RESEARCH

Optogenetic induction of hibernation-like state with modified human Opsin4 in mice.

Takahashi TM, Hirano A, Kanda T, Saito VM, Ashitomi H, Tanaka KZ, Yokoshiki Y, Masuda K, Yanagisawa M, Vogt KE, Tokuda T, Sakurai T.

Cell Rep Methods. 2022 Nov 14;2(11):100336. doi: 10.1016/j.crmeth.2022.100336. PMID: 36452866; PMCID: PMC9701604.

ORIGINAL RESEARCH

Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice

Emi Hasegawa, Ai Miyasaka, Katsuyasu Sakurai, Yoan Cherasse, Yulong Li, Takeshi Sakurai

Science . 2022 Mar 4;375(6584):994-1000. doi: 10.1126/science.abl6618. Epub 2022 Mar 3.

ORIGINAL RESEARCH

A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice

Uchida S, Soya S, Saito YC, Hirano A, Koga K, Tsuda M, Abe M, Sakimura K, Sakurai T.

Journal of Neuroscience 17 February 2021, 41 (7) 1582-1596; DOI: https://doi.org/10.1523/JNEUROSCI.0688-20.2020

ORIGINAL RESEARCH

Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β

Nakai A, Fujiyama T, Nagata N, Kashiwagi M, Ikkyu A, Takagi M, Tatsuzawa C, Tanaka K, Kakizaki M, Kanuka M, Kawano T, Mizuno S, Sugiyama F, Takahashi S, Funato H, Sakurai T, Yanagisawa M, Hayashi Y.

Genetics. 2020 Nov;216(3):753-764. doi: 10.1534/genetics.120.303435. Epub 2020 Sep 2.

REVIEW

Evolution of Orexin Neuropeptide System: Structure and Function

Soya S, Sakurai T.

Front Neurosci. 2020 Jul 10;14:691. doi: 10.3389/fnins.2020.00691. eCollection 2020.

ORIGINAL RESEARCH

A discrete neuronal circuit induces a hibernation-like state in rodents

Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T.

Nature. 2020 Jul;583(7814):109-114. doi: 10.1038/s41586-020-2163-6. Epub 2020 Jun 11.

ORIGINAL RESEARCH

Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation

Kumar D, Koyanagi I, Carrier-Ruiz A, Vergara P, Srinivasan S, Sugaya Y, Kasuya M, Yu TS, Vogt KE, Muratani M, Ohnishi T, Singh S, Teixeira CM, Chérasse Y, Naoi T, Wang SH, Nondhalee P, Osman BAH, Kaneko N, Sawamoto K, Kernie SG, Sakurai T, McHugh TJ, Kano M, Yanagisawa M, Sakaguchi M.

Neuron. 2020 Aug 5;107(3):552-565.e10. doi: 10.1016/j.neuron.2020.05.008. Epub 2020 Jun 4.

ORIGINAL RESEARCH

Narcolepsy – clinical spectrum, aetiopathophysiology, diagnosis and treatment

Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U, Khatami R, Koning F, Kornum BR, Lammers GJ, Liblau RS, Luppi PH, Mayer G, Pollmächer T, Sakurai T, Sallusto F, Scammell TE, Tafti M, Dauvilliers Y.

Nat Rev Neurol. 2019 Sep;15(9):519-539. doi: 10.1038/s41582-019-0226-9. Epub 2019 Jul 19.

ORIGINAL RESEARCH

Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice

Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K, Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K.

Addict Biol. 2020 Jan;25(1):e12723. doi: 10.1111/adb.12723. Epub 2019 Feb 7.

ORIGINAL RESEARCH

Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture

Saito YC, Tsujino N, Abe M, Yamazaki M, Sakimura K, Sakurai T.

Front Neurosci. 2018 Nov 30;12:892. doi: 10.3389/fnins.2018.00892. eCollection 2018.

REVIEW

Orexin as a modulator of fear-related behavior: Hypothalamic control of noradrenaline circuit

Soya S, Sakurai T.

Brain Res. 2020 Mar 15;1731:146037. doi: 10.1016/j.brainres.2018.11.032. Epub 2018 Nov 24.

ORIGINAL RESEARCH

Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells

Yeoh JW, James MH, Adams CD, Bains JS, Sakurai T, Aston-Jones G, Graham BA, Dayas CV.

Neuropharmacology. 2019 Aug;154:22-33. doi: 10.1016/j.neuropharm.2018.09.033. Epub 2018 Sep 22.

ORIGINAL RESEARCH

Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons

Saito YC, Maejima T, Nishitani M, Hasegawa E, Yanagawa Y, Mieda M, Sakurai T.

J Neurosci. 2018 Jul 11;38(28):6366-6378. doi: 10.1523/JNEUROSCI.2835-17.2018. Epub 2018 Jun 18.

ORIGINAL RESEARCH

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Wang Y, Cao L, Lee CY, Matsuo T, Wu K, Asher G, Tang L, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Chérasse Y, Zhou J, Li Y, Wang T, Zhan X, Miyoshi C, Irukayama Y, Cao J, Meeks JP, Gautron L, Wang Z, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H, Kobayakawa R, Kobayakawa K, Beutler B, Liu Q.

Nat Commun. 2018 May 23;9(1):2041. doi: 10.1038/s41467-018-04324-3.

ORIGINAL RESEARCH

Hypocretin/orexin deficiency decreases cocaine abuse liability

Steiner N, Rossetti C, Sakurai T, Yanagisawa M, de Lecea L, Magistretti PJ, Halfon O, Boutrel B.

Neuropharmacology. 2018 May 1;133:395-403. doi: 10.1016/j.neuropharm.2018.02.010. Epub 2018 Feb 15.

ORIGINAL RESEARCH

Hand-Foot Syndrome and Post-Progression Treatment Are the Good Predictors of Better Survival in Advanced Hepatocellular Carcinoma Treated with Sorafenib: A Multicenter Study

Ogawa C, Morita M, Omura A, Noda T, Kubo A, Matsunaka T, Tamaki H, Shibatoge M, Tsutsui A, Senoh T, Nagano T, Takaguchi K, Tani J, Morishita A, Yoneyama H, Masaki T, Moriya A, Ando M, Deguchi A, Kokudo Y, Minami Y, Ueshima K, Sakurai T, Nishida N, Kudo M.

Oncology. 2017;93 Suppl 1:113-119. doi: 10.1159/000481241. Epub 2017 Dec 20.

ORIGINAL RESEARCH

Orexin modulates behavioral fear expression through the locus coeruleus

Soya S, Takahashi TM, McHugh TJ, Maejima T, Herlitze S, Abe M, Sakimura K, Sakurai T.

Nat Commun. 2017 Nov 20;8(1):1606. doi: 10.1038/s41467-017-01782-z.

ORIGINAL RESEARCH

Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Thompson MD, Sakurai T, Rainero I, Maj MC, Kukkonen JP.

Pharmaceuticals (Basel). 2017 Oct 8;10(4):79. doi: 10.3390/ph10040079.

ORIGINAL RESEARCH

Excitation of GABAergic Neurons in the Bed Nucleus of the Stria Terminalis Triggers Immediate Transition from Non-Rapid Eye Movement Sleep to Wakefulness in Mice

Kodani S, Soya S, Sakurai T.

J Neurosci. 2017 Jul 26;37(30):7164-7176. doi: 10.1523/JNEUROSCI.0245-17.2017. Epub 2017 Jun 22.

ORIGINAL RESEARCH

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):5731-5736. doi: 10.1073/pnas.1700499114. Epub 2017 May 15.

PUBLICATIONS研究業績

Optogenetic induction of hibernation-like state with modified human Opsin4 in mice.

Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice

A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice

Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β

Evolution of Orexin Neuropeptide System: Structure and Function

A discrete neuronal circuit induces a hibernation-like state in rodents

Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation

Narcolepsy – clinical spectrum, aetiopathophysiology, diagnosis and treatment

Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice

Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture

Orexin as a modulator of fear-related behavior: Hypothalamic control of noradrenaline circuit

Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells

Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Hypocretin/orexin deficiency decreases cocaine abuse liability

Hand-Foot Syndrome and Post-Progression Treatment Are the Good Predictors of Better Survival in Advanced Hepatocellular Carcinoma Treated with Sorafenib: A Multicenter Study

Orexin modulates behavioral fear expression through the locus coeruleus

Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Excitation of GABAergic Neurons in the Bed Nucleus of the Stria Terminalis Triggers Immediate Transition from Non-Rapid Eye Movement Sleep to Wakefulness in Mice

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models