研究業績｜筑波大学国際統合睡眠医科学研究機構櫻井/平野研究室

ORIGINAL RESEARCH

Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Thompson MD, Sakurai T, Rainero I, Maj MC, Kukkonen JP.

Pharmaceuticals (Basel). 2017 Oct 8;10(4):79. doi: 10.3390/ph10040079.

ORIGINAL RESEARCH

Excitation of GABAergic Neurons in the Bed Nucleus of the Stria Terminalis Triggers Immediate Transition from Non-Rapid Eye Movement Sleep to Wakefulness in Mice

Kodani S, Soya S, Sakurai T.

J Neurosci. 2017 Jul 26;37(30):7164-7176. doi: 10.1523/JNEUROSCI.0245-17.2017. Epub 2017 Jun 22.

ORIGINAL RESEARCH

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):5731-5736. doi: 10.1073/pnas.1700499114. Epub 2017 May 15.

ORIGINAL RESEARCH

Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity

Hasegawa E, Maejima T, Yoshida T, Masseck OA, Herlitze S, Yoshioka M, Sakurai T, Mieda M.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3526-E3535. doi: 10.1073/pnas.1614552114. Epub 2017 Apr 10.

ORIGINAL RESEARCH

Angiomatoid fibrous histiocytoma of the scalp mimicking cutaneous angiosarcoma in incisional biopsy containing CD31-positive histiocytes: A potential histopathological pitfall

Kanameishi S, Kaku Y, Goto K, Ishida Y, Endo Y, Dainichi T, Sakurai T, Kataoka T, Miyagawa-Hayashino A, Kabashima K.

J Dermatol. 2018 Feb;45(2):235-237. doi: 10.1111/1346-8138.13843. Epub 2017 Mar 31.

ORIGINAL RESEARCH

Fine-Tuning Circadian Rhythms: The Importance of Bmal1 Expression in the Ventral Forebrain

Mieda M, Hasegawa E, Kessaris N, Sakurai T.

Front Neurosci. 2017 Feb 9;11:55. doi: 10.3389/fnins.2017.00055. eCollection 2017.

ORIGINAL RESEARCH

Low-Grade Neuroendocrine Carcinoma of the Skin (Primary Cutaneous Carcinoid Tumor) as a Distinctive Entity of Cutaneous Neuroendocrine Tumors: A Clinicopathologic Study of 3 Cases With Literature Review

Goto K, Anan T, Nakatsuka T, Kaku Y, Sakurai T, Fukumoto T, Kimura T, Shibata A.

Am J Dermatopathol. 2017 Apr;39(4):250-258. doi: 10.1097/DAD.0000000000000657.

ORIGINAL RESEARCH

Odour-induced analgesia mediated by hypothalamic orexin neurons in mice

Tashiro S, Yamaguchi R, Ishikawa S, Sakurai T, Kajiya K, Kanmura Y, Kuwaki T, Kashiwadani H.

Sci Rep. 2016 Nov 15;6:37129. doi: 10.1038/srep37129.

ORIGINAL RESEARCH

QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior

Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T.

PLoS One. 2016 Nov 11;11(11):e0164716. doi: 10.1371/journal.pone.0164716. eCollection 2016.

ORIGINAL RESEARCH

Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice

Tsuneki H, Kon K, Ito H, Yamazaki M, Takahara S, Toyooka N, Ishii Y, Sasahara M, Wada T, Yanagisawa M, Sakurai T, Sasaoka T.

Endocrinology. 2016 Nov;157(11):4146-4157. doi: 10.1210/en.2016-1404. Epub 2016 Sep 15.

ORIGINAL RESEARCH

Manipulating the Cellular Circadian Period of Arginine Vasopressin Neurons Alters the Behavioral Circadian Period

Mieda M, Okamoto H, Sakurai T.

Curr Biol. 2016 Sep 26;26(18):2535-2542. doi: 10.1016/j.cub.2016.07.022. Epub 2016 Aug 25.

ORIGINAL RESEARCH

Mesolimbic neuropeptide W coordinates stress responses under novel environments

Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6023-8. doi: 10.1073/pnas.1518658113. Epub 2016 May 2.

ORIGINAL RESEARCH

Comprehensive Behavioral Analysis of Male Ox1r (-/-) Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior

Abbas MG, Shoji H, Soya S, Hondo M, Miyakawa T, Sakurai T.

Front Behav Neurosci. 2015 Dec 10;9:324. doi: 10.3389/fnbeh.2015.00324. eCollection 2015.

ORIGINAL RESEARCH

Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury

Ayuzawa N, Nagase M, Ueda K, Nishimoto M, Kawarazaki W, Marumo T, Aiba A, Sakurai T, Shindo T, Fujita T.

Hypertension. 2016 Jan;67(1):99-106. doi: 10.1161/HYPERTENSIONAHA.115.06054. Epub 2015 Nov 2.

ORIGINAL RESEARCH

Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice

Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.

Endocrinology. 2016 Jan;157(1):195-206. doi: 10.1210/en.2015-1488. Epub 2015 Oct 22.

ORIGINAL RESEARCH

Hypocretin/orexin prevents recovery from sickness

Tanaka S, Toyoda H, Honda Y, Seki Y, Sakurai T, Honda K, Kodama T.

Biomed Rep. 2015 Sep;3(5):648-650. doi: 10.3892/br.2015.491. Epub 2015 Jul 17.

ORIGINAL RESEARCH

Messenger RNA expression profile of sleep-related genes in peripheral blood cells in patients with chronic kidney disease

Kitajima S, Iwata Y, Furuichi K, Sagara A, Shinozaki Y, Toyama T, Sakai N, Shimizu M, Sakurai T, Kaneko S, Wada T.

Clin Exp Nephrol. 2016 Apr;20(2):218-25. doi: 10.1007/s10157-015-1150-y. Epub 2015 Sep 20.

ORIGINAL RESEARCH

Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies

Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, Tagami M, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Ohi K, Hashimoto R, Tanisawa K, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Irukayama-Tomobe Y, Saito YC, Sakurai T, Hayashida M, Sugimura H, Ikeda K.

Mol Brain. 2015 Aug 20;8:50. doi: 10.1186/s13041-015-0142-x.

ORIGINAL RESEARCH

Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm

Mieda M, Ono D, Hasegawa E, Okamoto H, Honma K, Honma S, Sakurai T.

Neuron. 2015 Mar 4;85(5):1103-16. doi: 10.1016/j.neuron.2015.02.005.

ORIGINAL RESEARCH

The role of orexin in motivated behaviours

Sakurai T.

Nat Rev Neurosci. 2014 Nov;15(11):719-31. doi: 10.1038/nrn3837. Epub 2014 Oct 10.

PUBLICATIONS研究業績

Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Excitation of GABAergic Neurons in the Bed Nucleus of the Stria Terminalis Triggers Immediate Transition from Non-Rapid Eye Movement Sleep to Wakefulness in Mice

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity

Angiomatoid fibrous histiocytoma of the scalp mimicking cutaneous angiosarcoma in incisional biopsy containing CD31-positive histiocytes: A potential histopathological pitfall

Fine-Tuning Circadian Rhythms: The Importance of Bmal1 Expression in the Ventral Forebrain

Low-Grade Neuroendocrine Carcinoma of the Skin (Primary Cutaneous Carcinoid Tumor) as a Distinctive Entity of Cutaneous Neuroendocrine Tumors: A Clinicopathologic Study of 3 Cases With Literature Review

Odour-induced analgesia mediated by hypothalamic orexin neurons in mice

QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior

Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice

Manipulating the Cellular Circadian Period of Arginine Vasopressin Neurons Alters the Behavioral Circadian Period

Mesolimbic neuropeptide W coordinates stress responses under novel environments

Comprehensive Behavioral Analysis of Male Ox1r (-/-) Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior

Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury

Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice

Hypocretin/orexin prevents recovery from sickness

Messenger RNA expression profile of sleep-related genes in peripheral blood cells in patients with chronic kidney disease

Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies

Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm

The role of orexin in motivated behaviours