PUBLICATIONS研究業績

Roles of orexins in the regulation of body weight homeostasis

Sakurai T.

Obes Res Clin Pract. 2014 Sep-Oct;8(5):e414-20. doi: 10.1016/j.orcp.2013.12.001. Epub 2013 Dec 28.

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Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice

Tsuneki H, Tokai E, Nakamura Y, Takahashi K, Fujita M, Asaoka T, Kon K, Anzawa Y, Wada T, Takasaki I, Kimura K, Inoue H, Yanagisawa M, Sakurai T, Sasaoka T.

Diabetes. 2015 Feb;64(2):459-70. doi: 10.2337/db14-0695. Epub 2014 Sep 23.

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OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

Thompson MD, Xhaard H, Sakurai T, Rainero I, Kukkonen JP.

Front Neurosci. 2014 May 6;8:57. doi: 10.3389/fnins.2014.00057. eCollection 2014.

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Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function

Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A.

J Neurosci. 2014 May 7;34(19):6495-509. doi: 10.1523/JNEUROSCI.0073-14.2014.

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Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons

Schöne C, Apergis-Schoute J, Sakurai T, Adamantidis A, Burdakov D.

Cell Rep. 2014 May 8;7(3):697-704. doi: 10.1016/j.celrep.2014.03.055. Epub 2014 Apr 24.

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Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice

Etori K, Saito YC, Tsujino N, Sakurai T.

Front Neurosci. 2014 Jan 31;8:8. doi: 10.3389/fnins.2014.00008. eCollection 2014.

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Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

Hasegawa E, Yanagisawa M, Sakurai T, Mieda M.

J Clin Invest. 2014 Feb;124(2):604-16. doi: 10.1172/JCI71017. Epub 2014 Jan 2.

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GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons

Saito YC, Tsujino N, Hasegawa E, Akashi K, Abe M, Mieda M, Sakimura K, Sakurai T.

Front Neural Circuits. 2013 Dec 2;7:192. doi: 10.3389/fncir.2013.00192. eCollection 2013.

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Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation

Soya S, Shoji H, Hasegawa E, Hondo M, Miyakawa T, Yanagisawa M, Mieda M, Sakurai T.

J Neurosci. 2013 Sep 4;33(36):14549-57. doi: 10.1523/JNEUROSCI.1130-13.2013.

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Orexin neurons are indispensable for prostaglandin E2-induced fever and defence against environmental cooling in mice

Takahashi Y, Zhang W, Sameshima K, Kuroki C, Matsumoto A, Sunanaga J, Kono Y, Sakurai T, Kanmura Y, Kuwaki T.

J Physiol. 2013 Nov 15;591(22):5623-43. doi: 10.1113/jphysiol.2013.261271. Epub 2013 Aug 19.

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Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice

Tsujino N, Tsunematsu T, Uchigashima M, Konno K, Yamanaka A, Kobayashi K, Watanabe M, Koyama Y, Sakurai T.

PLoS One. 2013 Jul 29;8(7):e70012. doi: 10.1371/journal.pone.0070012. Print 2013.

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Orexin-neuromodulated cerebellar circuit controls redistribution of arterial blood flows for defense behavior in rabbits

Nisimaru N, Mittal C, Shirai Y, Sooksawate T, Anandaraj P, Hashikawa T, Nagao S, Arata A, Sakurai T, Yamamoto M, Ito M.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14124-31. doi: 10.1073/pnas.1312804110. Epub 2013 Aug 2.

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Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states

Furutani N, Hondo M, Kageyama H, Tsujino N, Mieda M, Yanagisawa M, Shioda S, Sakurai T.

PLoS One. 2013 Apr 19;8(4):e62391. doi: 10.1371/journal.pone.0062391. Print 2013.

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Hypocretin/orexin neurons contribute to hippocampus-dependent social memory and synaptic plasticity in mice

Yang L, Zou B, Xiong X, Pascual C, Xie J, Malik A, Xie J, Sakurai T, Xie XS.

J Neurosci. 2013 Mar 20;33(12):5275-84. doi: 10.1523/JNEUROSCI.3200-12.2013.

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Hypothalamic orexin prevents hepatic insulin resistance induced by social defeat stress in mice

Tsuneki H, Tokai E, Sugawara C, Wada T, Sakurai T, Sasaoka T.

Neuropeptides. 2013 Jun;47(3):213-9. doi: 10.1016/j.npep.2013.02.002. Epub 2013 Mar 16.

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Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation

Xiong X, White RE, Xu L, Yang L, Sun X, Zou B, Pascual C, Sakurai T, Giffard RG, Xie XS.

Stroke. 2013 Mar;44(3):764-70. doi: 10.1161/STROKEAHA.112.681700. Epub 2013 Jan 24.

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Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ

Schöne C, Cao ZF, Apergis-Schoute J, Adamantidis A, Sakurai T, Burdakov D.

J Neurosci. 2012 Sep 5;32(36):12437-43. doi: 10.1523/JNEUROSCI.0706-12.2012.

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A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions

Watanabe N, Wada M, Irukayama-Tomobe Y, Ogata Y, Tsujino N, Suzuki M, Furutani N, Sakurai T, Yamamoto M.

PLoS One. 2012;7(4):e35390. doi: 10.1371/journal.pone.0035390. Epub 2012 Apr 24.

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[Connectomics of orexin-producing neurons: analysis using mouse models]

Sakurai T.

Nihon Shinkei Seishin Yakurigaku Zasshi. 2011 Nov;31(5-6):223-9.

Bmal1 in the nervous system is essential for normal adaptation of circadian locomotor activity and food intake to periodic feeding

Mieda M, Sakurai T.

J Neurosci. 2011 Oct 26;31(43):15391-6. doi: 10.1523/JNEUROSCI.2801-11.2011.

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