PUBLICATIONS研究業績

Orexin neurons receive glycinergic innervations

Hondo M, Furutani N, Yamasaki M, Watanabe M, Sakurai T.

PLoS One. 2011;6(9):e25076. doi: 10.1371/journal.pone.0025076. Epub 2011 Sep 16.

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Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

Sasaki K, Suzuki M, Mieda M, Tsujino N, Roth B, Sakurai T.

PLoS One. 2011;6(5):e20360. doi: 10.1371/journal.pone.0020360. Epub 2011 May 27.

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Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal

Sakurai T, Mieda M.

Trends Pharmacol Sci. 2011 Aug;32(8):451-62. doi: 10.1016/j.tips.2011.03.007. Epub 2011 May 11.

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Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep

Mieda M, Hasegawa E, Kisanuki YY, Sinton CM, Yanagisawa M, Sakurai T.

J Neurosci. 2011 Apr 27;31(17):6518-26. doi: 10.1523/JNEUROSCI.6506-10.2011.

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Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice

Liu M, Blanco-Centurion C, Konadhode R, Begum S, Pelluru D, Gerashchenko D, Sakurai T, Yanagisawa M, van den Pol AN, Shiromani PJ.

J Neurosci. 2011 Apr 20;31(16):6028-40. doi: 10.1523/JNEUROSCI.6069-10.2011.

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Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory

Nagata-Kuroiwa R, Furutani N, Hara J, Hondo M, Ishii M, Abe T, Mieda M, Tsujino N, Motoike T, Yanagawa Y, Kuwaki T, Yamamoto M, Yanagisawa M, Sakurai T.

PLoS One. 2011 Feb 24;6(2):e16972. doi: 10.1371/journal.pone.0016972.

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Decreased intake of sucrose solutions in orexin knockout mice

Matsuo E, Mochizuki A, Nakayama K, Nakamura S, Yamamoto T, Shioda S, Sakurai T, Yanagisawa M, Shiuchi T, Minokoshi Y, Inoue T.

J Mol Neurosci. 2011 Feb;43(2):217-24. doi: 10.1007/s12031-010-9475-1. Epub 2010 Nov 18.

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[Orexin (ORX)]

Sakurai T.

Nihon Rinsho. 2010 Jul;68 Suppl 7:633-6.

Orexin neurons are indispensable for stress-induced thermogenesis in mice

Zhang W, Sunanaga J, Takahashi Y, Mori T, Sakurai T, Kanmura Y, Kuwaki T.

J Physiol. 2010 Nov 1;588(Pt 21):4117-29. doi: 10.1113/jphysiol.2010.195099. Epub 2010 Aug 31.

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Ectopic overexpression of orexin alters sleep/wakefulness states and muscle tone regulation during REM sleep in mice

Willie JT, Takahira H, Shibahara M, Hara J, Nomiyama M, Yanagisawa M, Sakurai T.

J Mol Neurosci. 2011 Feb;43(2):155-61. doi: 10.1007/s12031-010-9437-7. Epub 2010 Aug 14.

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The orexin system: roles in sleep/wake regulation

Sakurai T, Mieda M, Tsujino N.

Ann N Y Acad Sci. 2010 Jul;1200:149-61. doi: 10.1111/j.1749-6632.2010.05513.x.

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Activation of bombesin receptor subtype-3 influences activity of orexin neurons by both direct and indirect pathways

Furutani N, Hondo M, Tsujino N, Sakurai T.

J Mol Neurosci. 2010 Sep;42(1):106-11. doi: 10.1007/s12031-010-9382-5. Epub 2010 May 14.

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Circadian characteristics of mice depleted with GPR7

Uchio N, Doi M, Matsuo M, Yamazaki F, Mizoro Y, Hondo M, Sakurai T, Okamura H.

Biomed Res. 2009 Dec;30(6):357-64. doi: 10.2220/biomedres.30.357.

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Characterization of sleep-wake patterns in a novel transgenic mouse line overexpressing human prepro-orexin/hypocretin

Mäkelä KA, Wigren HK, Zant JC, Sakurai T, Alhonen L, Kostin A, Porkka-Heiskanen T, Herzig KH.

Acta Physiol (Oxf). 2010 Mar;198(3):237-49. doi: 10.1111/j.1748-1716.2009.02068.x. Epub 2009 Dec 10.

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Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system

Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y.

Cell Metab. 2009 Dec;10(6):466-80. doi: 10.1016/j.cmet.2009.09.013.

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Monoaminergic neuronal changes in orexin deficient mice

Mori T, Ito S, Kuwaki T, Yanagisawa M, Sakurai T, Sawaguchi T.

Neuropharmacology. 2010 Mar-Apr;58(4-5):826-32. doi: 10.1016/j.neuropharm.2009.08.009. Epub 2009 Aug 22.

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Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states

Hondo M, Nagai K, Ohno K, Kisanuki Y, Willie JT, Watanabe T, Yanagisawa M, Sakurai T.

Acta Physiol (Oxf). 2010 Mar;198(3):287-94. doi: 10.1111/j.1748-1716.2009.02032.x. Epub 2009 Aug 20.

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Integrative physiology of orexins and orexin receptors

Mieda M, Sakurai T.

CNS Neurol Disord Drug Targets. 2009 Aug;8(4):281-95. doi: 10.2174/187152709788921663.

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Attenuated phrenic long-term facilitation in orexin neuron-ablated mice

Toyama S, Sakurai T, Tatsumi K, Kuwaki T.

Respir Physiol Neurobiol. 2009 Sep 30;168(3):295-302. doi: 10.1016/j.resp.2009.07.025. Epub 2009 Aug 5.

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Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system

Tsujino N, Sakurai T.

Pharmacol Rev. 2009 Jun;61(2):162-76. doi: 10.1124/pr.109.001321.

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