PUBLICATIONS研究業績

Dexmedetomidine inhibits muscarinic type 3 receptors expressed in Xenopus oocytes and muscarine-induced intracellular Ca2+ elevation in cultured rat dorsal root ganglia cells

Takizuka A, Minami K, Uezono Y, Horishita T, Yokoyama T, Shiraishi M, Sakurai T, Shigematsu A, Ueta Y.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Jul;375(5):293-301. doi: 10.1007/s00210-007-0168-4. Epub 2007 Jun 12.

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Effects of anesthetics on the function of orexin-1 receptors expressed in Xenopus oocytes

Minami K, Uezono Y, Sakurai T, Horishita T, Shiraishi M, Ueta Y.

Pharmacology. 2007;79(4):236-42. doi: 10.1159/000101713. Epub 2007 Apr 13.

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Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy

Zhang S, Zeitzer JM, Sakurai T, Nishino S, Mignot E.

J Physiol. 2007 Jun 1;581(Pt 2):649-63. doi: 10.1113/jphysiol.2007.129510. Epub 2007 Mar 22.

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The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

Sakurai T.

Nat Rev Neurosci. 2007 Mar;8(3):171-81. doi: 10.1038/nrn2092. Epub 2007 Feb 14.

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[Endothelin-1 gene]

Hara J, Sakurai T.

Nihon Rinsho. 2006 Jul;64 Suppl 5:396-8.

Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis

Sakurai T.

CNS Neurol Disord Drug Targets. 2006 Jun;5(3):313-25. doi: 10.2174/187152706777452218.

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Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain

Kitamura Y, Tanaka H, Motoike T, Ishii M, Williams SC, Yanagisawa M, Sakurai T.

Brain Res. 2006 Jun 6;1093(1):123-34. doi: 10.1016/j.brainres.2006.03.041. Epub 2006 May 15.

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A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice

Takayasu S, Sakurai T, Iwasaki S, Teranishi H, Yamanaka A, Williams SC, Iguchi H, Kawasawa YI, Ikeda Y, Sakakibara I, Ohno K, Ioka RX, Murakami S, Dohmae N, Xie J, Suda T, Motoike T, Ohuchi T, Yanagisawa M, Sakai J.

Proc Natl Acad Sci U S A. 2006 May 9;103(19):7438-43. doi: 10.1073/pnas.0602371103. Epub 2006 Apr 28.

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Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models

Fujiki N, Yoshida Y, Zhang S, Sakurai T, Yanagisawa M, Nishino S.

Peptides. 2006 Sep;27(9):2326-31. doi: 10.1016/j.peptides.2006.03.011. Epub 2006 Apr 19.

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GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus

Xie X, Crowder TL, Yamanaka A, Morairty SR, Lewinter RD, Sakurai T, Kilduff TS.

J Physiol. 2006 Jul 15;574(Pt 2):399-414. doi: 10.1113/jphysiol.2006.108266. Epub 2006 Apr 20.

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Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner

Yamanaka A, Muraki Y, Ichiki K, Tsujino N, Kilduff TS, Goto K, Sakurai T.

J Neurophysiol. 2006 Jul;96(1):284-98. doi: 10.1152/jn.01361.2005. Epub 2006 Apr 12.

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Elevated body temperature during sleep in orexin knockout mice

Mochizuki T, Klerman EB, Sakurai T, Scammell TE.

Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R533-40. doi: 10.1152/ajpregu.00887.2005.

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Regulation by orexin of feeding behaviour and locomotor activity in the goldfish

Nakamachi T, Matsuda K, Maruyama K, Miura T, Uchiyama M, Funahashi H, Sakurai T, Shioda S.

J Neuroendocrinol. 2006 Apr;18(4):290-7. doi: 10.1111/j.1365-2826.2006.01415.x.

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Reduced expression of the endothelin receptor type B gene in piebald mice caused by insertion of a retroposon-like element in intron 1

Yamada T, Ohtani S, Sakurai T, Tsuji T, Kunieda T, Yanagisawa M.

J Biol Chem. 2006 Apr 21;281(16):10799-807. doi: 10.1074/jbc.M512618200. Epub 2006 Feb 24.

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Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor

Toshinai K, Yamaguchi H, Sun Y, Smith RG, Yamanaka A, Sakurai T, Date Y, Mondal MS, Shimbara T, Kawagoe T, Murakami N, Miyazato M, Kangawa K, Nakazato M.

Endocrinology. 2006 May;147(5):2306-14. doi: 10.1210/en.2005-1357. Epub 2006 Feb 16.

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Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice

Zhang W, Sakurai T, Fukuda Y, Kuwaki T.

Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1654-63. doi: 10.1152/ajpregu.00704.2005. Epub 2006 Jan 12.

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Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine

Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, Sakurai T, Yanagisawa M, Nakamachi T, Shioda S, Suzuki T.

J Neurosci. 2006 Jan 11;26(2):398-405. doi: 10.1523/JNEUROSCI.2761-05.2006.

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Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury

Yanagita M, Okuda T, Endo S, Tanaka M, Takahashi K, Sugiyama F, Kunita S, Takahashi S, Fukatsu A, Yanagisawa M, Kita T, Sakurai T.

J Clin Invest. 2006 Jan;116(1):70-9. doi: 10.1172/JCI25445. Epub 2005 Dec 8.

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Concomitant loss of dynorphin, NARP, and orexin in narcolepsy

Crocker A, España RA, Papadopoulou M, Saper CB, Faraco J, Sakurai T, Honda M, Mignot E, Scammell TE.

Neurology. 2005 Oct 25;65(8):1184-8. doi: 10.1212/01.wnl.0000168173.71940.ab. Epub 2005 Sep 14.

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[Orexin]

Sakurai T.

Nihon Rinsho. 2005 Aug;63 Suppl 8:600-2.