研究業績｜筑波大学国際統合睡眠医科学研究機構櫻井/平野研究室

ORIGINAL RESEARCH

Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor

Tsujino N, Yamanaka A, Ichiki K, Muraki Y, Kilduff TS, Yagami K, Takahashi S, Goto K, Sakurai T.

J Neurosci. 2005 Aug 10;25(32):7459-69. doi: 10.1523/JNEUROSCI.1193-05.2005.

ORIGINAL RESEARCH

Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects

Meerabux J, Iwayama Y, Sakurai T, Ohba H, Toyota T, Yamada K, Nagata R, Irukayama-Tomobe Y, Shimizu H, Yoshitsugu K, Ohta K, Yoshikawa T.

Biol Psychiatry. 2005 Sep 1;58(5):401-7. doi: 10.1016/j.biopsych.2005.04.015.

ORIGINAL RESEARCH

Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues

Ikeda Y, Iguchi H, Nakata M, Ioka RX, Tanaka T, Iwasaki S, Magoori K, Takayasu S, Yamamoto TT, Kodama T, Yada T, Sakurai T, Yanagisawa M, Sakai J.

Biochem Biophys Res Commun. 2005 Aug 5;333(3):778-86. doi: 10.1016/j.bbrc.2005.06.005.

ORIGINAL RESEARCH

Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy homeostasis

Sakurai T.

Sleep Med Rev. 2005 Aug;9(4):231-41. doi: 10.1016/j.smrv.2004.07.007.

ORIGINAL RESEARCH

Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions

Hara J, Yanagisawa M, Sakurai T.

Neurosci Lett. 2005 Jun 3;380(3):239-42. doi: 10.1016/j.neulet.2005.01.046. Epub 2005 Feb 8.

ORIGINAL RESEARCH

Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice

Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, Muraki Y, Kageyama H, Kunita S, Takahashi S, Goto K, Koyama Y, Shioda S, Yanagisawa M.

Neuron. 2005 Apr 21;46(2):297-308. doi: 10.1016/j.neuron.2005.03.010.

ORIGINAL RESEARCH

Reverse pharmacology of orexin: from an orphan GPCR to integrative physiology

Sakurai T.

Regul Pept. 2005 Mar 15;126(1-2):3-10. doi: 10.1016/j.regpep.2004.08.006.

ORIGINAL RESEARCH

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response

Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L.

J Neurosci. 2004 Dec 15;24(50):11439-48. doi: 10.1523/JNEUROSCI.3459-04.2004.

ORIGINAL RESEARCH

Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice

Akiyama M, Yuasa T, Hayasaka N, Horikawa K, Sakurai T, Shibata S.

Eur J Neurosci. 2004 Dec;20(11):3054-62. doi: 10.1111/j.1460-9568.2004.03749.x.

ORIGINAL RESEARCH

Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness

Mieda M, Williams SC, Sinton CM, Richardson JA, Sakurai T, Yanagisawa M.

J Neurosci. 2004 Nov 17;24(46):10493-501. doi: 10.1523/JNEUROSCI.3171-04.2004.

ORIGINAL RESEARCH

[Regulation of endothelin-1 gene expression]

Hara J, Sakurai T.

Nihon Rinsho. 2004 Sep;62 Suppl 9:591-3.

ORIGINAL RESEARCH

[Endothelin receptor and intracellular signaling]

Hara J, Sakurai T.

Nihon Rinsho. 2004 Sep;62 Suppl 9:588-90.

ORIGINAL RESEARCH

Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor

Muraki Y, Yamanaka A, Tsujino N, Kilduff TS, Goto K, Sakurai T.

J Neurosci. 2004 Aug 11;24(32):7159-66. doi: 10.1523/JNEUROSCI.1027-04.2004.

ORIGINAL RESEARCH

Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette’s syndrome comorbidity

Thompson MD, Comings DE, Abu-Ghazalah R, Jereseh Y, Lin L, Wade J, Sakurai T, Tokita S, Yoshida T, Tanaka H, Yanagisawa M, Burnham WM, Moldofsky H.

Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):69-75. doi: 10.1002/ajmg.b.30047.

ORIGINAL RESEARCH

Behavioral state instability in orexin knock-out mice

Mochizuki T, Crocker A, McCormack S, Yanagisawa M, Sakurai T, Scammell TE.

J Neurosci. 2004 Jul 14;24(28):6291-300. doi: 10.1523/JNEUROSCI.0586-04.2004.

ORIGINAL RESEARCH

Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat

Beuckmann CT, Sinton CM, Williams SC, Richardson JA, Hammer RE, Sakurai T, Yanagisawa M.

J Neurosci. 2004 May 5;24(18):4469-77. doi: 10.1523/JNEUROSCI.5560-03.2004.

ORIGINAL RESEARCH

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4649-54. doi: 10.1073/pnas.0400590101. Epub 2004 Mar 16.

ORIGINAL RESEARCH

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus

Muroya S, Funahashi H, Yamanaka A, Kohno D, Uramura K, Nambu T, Shibahara M, Kuramochi M, Takigawa M, Yanagisawa M, Sakurai T, Shioda S, Yada T.

Eur J Neurosci. 2004 Mar;19(6):1524-34. doi: 10.1111/j.1460-9568.2004.03255.x.

ORIGINAL RESEARCH

USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney

Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T.

Biochem Biophys Res Commun. 2004 Apr 2;316(2):490-500. doi: 10.1016/j.bbrc.2004.02.075.

ORIGINAL RESEARCH

Roles of orexins in the regulation of feeding and arousal

Sakurai T.

Sleep Med. 2002 Dec;3 Suppl 2:S3-9. doi: 10.1016/s1389-9457(02)00156-9.

PUBLICATIONS研究業績

Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor

Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects

Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues

Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy homeostasis

Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions

Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice

Reverse pharmacology of orexin: from an orphan GPCR to integrative physiology

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response

Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice

Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness

[Regulation of endothelin-1 gene expression]

[Endothelin receptor and intracellular signaling]

Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor

Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette’s syndrome comorbidity

Behavioral state instability in orexin knock-out mice

Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus

USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney

Roles of orexins in the regulation of feeding and arousal