PUBLICATIONS研究業績

Orexin (hypocretin) neurons contain dynorphin

Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, Saper CB, Scammell TE.

J Neurosci. 2001 Oct 1;21(19):RC168. doi: 10.1523/JNEUROSCI.21-19-j0003.2001.

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Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus

Muroya S, Uramura K, Sakurai T, Takigawa M, Yada T.

Neurosci Lett. 2001 Aug 31;309(3):165-8. doi: 10.1016/s0304-3940(01)02053-5.

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Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity

Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, Sakurai T.

Neuron. 2001 May;30(2):345-54. doi: 10.1016/s0896-6273(01)00293-8.

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Functional analysis of five endothelin-B receptor mutations found in human Hirschsprung disease patients

Abe Y, Sakurai T, Yamada T, Nakamura T, Yanagisawa M, Goto K.

Biochem Biophys Res Commun. 2000 Aug 28;275(2):524-31. doi: 10.1006/bbrc.2000.3291.

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[2-molecular neurobiology of orexins]

Sakurai T.

Seikagaku. 2000 Jun;72(6):455-60.

Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

Nakamura T, Uramura K, Nambu T, Yada T, Goto K, Yanagisawa M, Sakurai T.

Brain Res. 2000 Aug 4;873(1):181-7. doi: 10.1016/s0006-8993(00)02555-5.

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Orexins suppress catecholamine synthesis and secretion in cultured PC12 cells

Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Ishii K, Goto K, Nakai T.

Biochem Biophys Res Commun. 2000 Aug 2;274(2):310-5. doi: 10.1006/bbrc.2000.3137.

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Subtype-specific trafficking of endothelin receptors

Abe Y, Nakayama K, Yamanaka A, Sakurai T, Goto K.

J Biol Chem. 2000 Mar 24;275(12):8664-71. doi: 10.1074/jbc.275.12.8664.

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Orexin-induced food intake involves neuropeptide Y pathway

Yamanaka A, Kunii K, Nambu T, Tsujino N, Sakai A, Matsuzaki I, Miwa Y, Goto K, Sakurai T.

Brain Res. 2000 Mar 24;859(2):404-9. doi: 10.1016/s0006-8993(00)02043-6.

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Endothelin-1 concentration increases in the cerebrospinal fluid in cerebral vasospasm caused by subarachnoid hemorrhage

Suzuki K, Meguro K, Sakurai T, Saitoh Y, Takeuchi S, Nose T.

Surg Neurol. 2000 Feb;53(2):131-5. doi: 10.1016/s0090-3019(99)00179-2.

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Pathophysiological role of endothelins in pulmonary microcirculatory disorders due to intestinal ischemia and reperfusion

Mitsuoka H, Unno N, Sakurai T, Kaneko H, Suzuki S, Konno H, Terakawa S, Nakamura S.

J Surg Res. 1999 Dec;87(2):143-51. doi: 10.1006/jsre.1999.5694.

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Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight

Yamanaka A, Sakurai T, Katsumoto T, Yanagisawa M, Goto K.

Brain Res. 1999 Dec 4;849(1-2):248-52. doi: 10.1016/s0006-8993(99)01905-8.

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Orexins and orexin receptors: implication in feeding behavior

Sakurai T.

Regul Pept. 1999 Nov 30;85(1):25-30. doi: 10.1016/s0167-0115(99)00076-2.

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Structure, tissue distribution, and pharmacological characterization of Xenopus orexins

Shibahara M, Sakurai T, Nambu T, Takenouchi T, Iwaasa H, Egashira SI, Ihara M, Goto K.

Peptides. 1999;20(10):1169-76. doi: 10.1016/s0196-9781(99)00120-5.

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Orexins/hypocretins regulate drinking behaviour

Kunii K, Yamanaka A, Nambu T, Matsuzaki I, Goto K, Sakurai T.

Brain Res. 1999 Sep 18;842(1):256-61. doi: 10.1016/s0006-8993(99)01884-3.

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Structure and function of human prepro-orexin gene

Sakurai T, Moriguchi T, Furuya K, Kajiwara N, Nakamura T, Yanagisawa M, Goto K.

J Biol Chem. 1999 Jun 18;274(25):17771-6. doi: 10.1074/jbc.274.25.17771.

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Distribution of orexin neurons in the adult rat brain

Nambu T, Sakurai T, Mizukami K, Hosoya Y, Yanagisawa M, Goto K.

Brain Res. 1999 May 8;827(1-2):243-60. doi: 10.1016/s0006-8993(99)01336-0.

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Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia

Moriguchi T, Sakurai T, Nambu T, Yanagisawa M, Goto K.

Neurosci Lett. 1999 Apr 2;264(1-3):101-4. doi: 10.1016/s0304-3940(99)00177-9.

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Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Date Y, Ueta Y, Yamashita H, Yamaguchi H, Matsukura S, Kangawa K, Sakurai T, Yanagisawa M, Nakazato M.

Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):748-53. doi: 10.1073/pnas.96.2.748.

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Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, Kelly J, Tatro JB, Hoffman GE, Ollmann MM, Barsh GS, Sakurai T, Yanagisawa M, Elmquist JK.

J Comp Neurol. 1998 Dec 28;402(4):442-59.