PUBLICATIONS研究業績

The human prepro-orexin gene regulatory region that activates gene expression in the lateral region and represses it in the medial regions of the hypothalamus

Moriguchi T, Sakurai T, Takahashi S, Goto K, Yamamoto M.

J Biol Chem. 2002 May 10;277(19):16985-92. doi: 10.1074/jbc.M107962200. Epub 2002 Feb 19.

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Plasma orexin-A is lower in patients with narcolepsy

Higuchi S, Usui A, Murasaki M, Matsushita S, Nishioka N, Yoshino A, Matsui T, Muraoka H, Ishizuka Y, Kanba S, Sakurai T.

Neurosci Lett. 2002 Jan 25;318(2):61-4. doi: 10.1016/s0304-3940(01)02476-4.

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Effects of orexin on cultured porcine adrenal medullary and cortex cells

Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Goto K, Nakai T.

Regul Pept. 2002 Mar 15;104(1-3):125-30. doi: 10.1016/s0167-0115(01)00356-1.

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Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Matsuzaki I, Sakurai T, Kunii K, Nakamura T, Yanagisawa M, Goto K.

Regul Pept. 2002 Mar 15;104(1-3):119-23. doi: 10.1016/s0167-0115(01)00355-x.

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Orexins activate histaminergic neurons via the orexin 2 receptor

Yamanaka A, Tsujino N, Funahashi H, Honda K, Guan JL, Wang QP, Tominaga M, Goto K, Shioda S, Sakurai T.

Biochem Biophys Res Commun. 2002 Feb 1;290(4):1237-45. doi: 10.1006/bbrc.2001.6318.

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Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus

Iqbal J, Pompolo S, Sakurai T, Clarke IJ.

J Neuroendocrinol. 2001 Dec;13(12):1033-41. doi: 10.1046/j.1365-2826.2001.00719.x.

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Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus

Iqbal J, Pompolo S, Murakami T, Grouzmann E, Sakurai T, Meister B, Clarke IJ.

Brain Res. 2001 Nov 30;920(1-2):55-64. doi: 10.1016/s0006-8993(01)02932-8.

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Orexin (hypocretin) neurons contain dynorphin

Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, Saper CB, Scammell TE.

J Neurosci. 2001 Oct 1;21(19):RC168. doi: 10.1523/JNEUROSCI.21-19-j0003.2001.

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Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus

Muroya S, Uramura K, Sakurai T, Takigawa M, Yada T.

Neurosci Lett. 2001 Aug 31;309(3):165-8. doi: 10.1016/s0304-3940(01)02053-5.

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Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity

Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, Sakurai T.

Neuron. 2001 May;30(2):345-54. doi: 10.1016/s0896-6273(01)00293-8.

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Functional analysis of five endothelin-B receptor mutations found in human Hirschsprung disease patients

Abe Y, Sakurai T, Yamada T, Nakamura T, Yanagisawa M, Goto K.

Biochem Biophys Res Commun. 2000 Aug 28;275(2):524-31. doi: 10.1006/bbrc.2000.3291.

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[2-molecular neurobiology of orexins]

Sakurai T.

Seikagaku. 2000 Jun;72(6):455-60.

Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

Nakamura T, Uramura K, Nambu T, Yada T, Goto K, Yanagisawa M, Sakurai T.

Brain Res. 2000 Aug 4;873(1):181-7. doi: 10.1016/s0006-8993(00)02555-5.

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Orexins suppress catecholamine synthesis and secretion in cultured PC12 cells

Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Ishii K, Goto K, Nakai T.

Biochem Biophys Res Commun. 2000 Aug 2;274(2):310-5. doi: 10.1006/bbrc.2000.3137.

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Subtype-specific trafficking of endothelin receptors

Abe Y, Nakayama K, Yamanaka A, Sakurai T, Goto K.

J Biol Chem. 2000 Mar 24;275(12):8664-71. doi: 10.1074/jbc.275.12.8664.

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Orexin-induced food intake involves neuropeptide Y pathway

Yamanaka A, Kunii K, Nambu T, Tsujino N, Sakai A, Matsuzaki I, Miwa Y, Goto K, Sakurai T.

Brain Res. 2000 Mar 24;859(2):404-9. doi: 10.1016/s0006-8993(00)02043-6.

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Endothelin-1 concentration increases in the cerebrospinal fluid in cerebral vasospasm caused by subarachnoid hemorrhage

Suzuki K, Meguro K, Sakurai T, Saitoh Y, Takeuchi S, Nose T.

Surg Neurol. 2000 Feb;53(2):131-5. doi: 10.1016/s0090-3019(99)00179-2.

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Pathophysiological role of endothelins in pulmonary microcirculatory disorders due to intestinal ischemia and reperfusion

Mitsuoka H, Unno N, Sakurai T, Kaneko H, Suzuki S, Konno H, Terakawa S, Nakamura S.

J Surg Res. 1999 Dec;87(2):143-51. doi: 10.1006/jsre.1999.5694.

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Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight

Yamanaka A, Sakurai T, Katsumoto T, Yanagisawa M, Goto K.

Brain Res. 1999 Dec 4;849(1-2):248-52. doi: 10.1016/s0006-8993(99)01905-8.

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Orexins and orexin receptors: implication in feeding behavior

Sakurai T.

Regul Pept. 1999 Nov 30;85(1):25-30. doi: 10.1016/s0167-0115(99)00076-2.

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