研究業績｜筑波大学国際統合睡眠医科学研究機構櫻井/平野研究室

ORIGINAL RESEARCH

Pulmonary hypertension caused by congestive heart failure is ameliorated by long-term application of an endothelin receptor antagonist. Increased expression of endothelin-1 messenger ribonucleic acid and endothelin-1-like immunoreactivity in the lung in congestive heart failure in rats

Sakai S, Miyauchi T, Sakurai T, Yamaguchi I, Kobayashi M, Goto K, Sugishita Y.

J Am Coll Cardiol. 1996 Nov 15;28(6):1580-8. doi: 10.1016/s0735-1097(96)00336-1.

ORIGINAL RESEARCH

Anticoagulant factor protein S inhibits the proliferation of rat astrocytes after injury

Tomobe YI, Hama H, Sakurai T, Fujimori A, Abe Y, Goto K.

Neurosci Lett. 1996 Aug 16;214(1):57-60. doi: 10.1016/0304-3940(96)12880-9.

ORIGINAL RESEARCH

Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure. Marked increase in endothelin-1 production in the failing heart

Sakai S, Miyauchi T, Sakurai T, Kasuya Y, Ihara M, Yamaguchi I, Goto K, Sugishita Y.

Circulation. 1996 Mar 15;93(6):1214-22. doi: 10.1161/01.cir.93.6.1214.

ORIGINAL RESEARCH

Ultraviolet B irradiation increases endothelin-1 and endothelin receptor expression in cultured human keratinocytes

Tsuboi R, Sato C, Oshita Y, Hama H, Sakurai T, Goto K, Ogawa H.

FEBS Lett. 1995 Sep 4;371(2):188-90. doi: 10.1016/0014-5793(95)00912-s.

ORIGINAL RESEARCH

Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors

Takigawa M, Sakurai T, Kasuya Y, Abe Y, Masaki T, Goto K.

Eur J Biochem. 1995 Feb 15;228(1):102-8. doi: 10.1111/j.1432-1033.1995.tb20236.x.

ORIGINAL RESEARCH

Altered production of endothelin-1 in the hypertrophied rat heart

Sakai S, Yorikane R, Miyauchi T, Sakurai T, Kasuya Y, Yamaguchi I, Sugishita Y, Goto K.

J Cardiovasc Pharmacol. 1995;26 Suppl 3:S452-5.

ORIGINAL RESEARCH

Endothelin-1-induced downregulation of ETB receptor mRNA: participation of cAMP

Asada S, Kasuya Y, Sakurai T, Masaki T, Goto K.

J Cardiovasc Pharmacol. 1995;26 Suppl 3:S272-5.

ORIGINAL RESEARCH

Endothelin-1 activates mitogen-activated protein kinases through two independent signalling pathways in rat astrocytes

Kasuya Y, Abe Y, Hama H, Sakurai T, Asada S, Masaki T, Goto K.

Biochem Biophys Res Commun. 1994 Nov 15;204(3):1325-33. doi: 10.1006/bbrc.1994.2608.

ORIGINAL RESEARCH

Molecular cloning of low-Ca(2+)-sensitive-type non-muscle alpha-actinin

Imamura M, Sakurai T, Ogawa Y, Ishikawa T, Goto K, Masaki T.

Eur J Biochem. 1994 Jul 15;223(2):395-401. doi: 10.1111/j.1432-1033.1994.tb19006.x.

ORIGINAL RESEARCH

Activin A stimulates mitogenesis in Swiss 3T3 fibroblasts without activation of mitogen-activated protein kinases

Sakurai T, Abe Y, Kasuya Y, Takuwa N, Shiba R, Yamashita T, Endo T, Goto K.

J Biol Chem. 1994 May 13;269(19):14118-22.

ORIGINAL RESEARCH

Endothelin-1 acts as an autocrine growth factor for normal human keratinocytes

Tsuboi R, Sato C, Shi CM, Nakamura T, Sakurai T, Ogawa H.

J Cell Physiol. 1994 May;159(2):213-20. doi: 10.1002/jcp.1041590204.

ORIGINAL RESEARCH

Human endothelin receptor ETB. Amino acid sequence requirements for super stable complex formation with its ligand

Takasuka T, Sakurai T, Goto K, Furuichi Y, Watanabe T.

J Biol Chem. 1994 Mar 11;269(10):7509-13.

ORIGINAL RESEARCH

Possible involvement of endothelin-1 in cardiac hypertrophy

Yorikane R, Sakai S, Miyauchi T, Sakurai T, Goto K.

Arzneimittelforschung. 1994 Mar;44(3A):412-5.

ORIGINAL RESEARCH

Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension

Miyauchi T, Yorikane R, Sakai S, Sakurai T, Okada M, Nishikibe M, Yano M, Yamaguchi I, Sugishita Y, Goto K.

Circ Res. 1993 Nov;73(5):887-97. doi: 10.1161/01.res.73.5.887.

ORIGINAL RESEARCH

Endothelins. Vascular actions and clinical implications

Sakurai T, Goto K.

Drugs. 1993 Nov;46(5):795-804. doi: 10.2165/00003495-199346050-00001.

ORIGINAL RESEARCH

Increased production of endothelin-1 in the hypertrophied rat heart due to pressure overload

Yorikane R, Sakai S, Miyauchi T, Sakurai T, Sugishita Y, Goto K.

FEBS Lett. 1993 Oct 11;332(1-2):31-4. doi: 10.1016/0014-5793(93)80476-b.

ORIGINAL RESEARCH

Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists

Sakamoto A, Yanagisawa M, Sawamura T, Enoki T, Ohtani T, Sakurai T, Nakao K, Toyo-oka T, Masaki T.

J Biol Chem. 1993 Apr 25;268(12):8547-53.

ORIGINAL RESEARCH

Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system

Okazaki H, Ishizaka N, Sakurai T, Kurokawa K, Goto K, Kumada M, Takuwa Y.

Biochem Biophys Res Commun. 1993 Feb 15;190(3):1104-9. doi: 10.1006/bbrc.1993.1163.

ORIGINAL RESEARCH

Altered expression of ETB-receptor mRNA in the lung of rats with pulmonary hypertension

Yorikane R, Miyauchi T, Sakai S, Sakurai T, Yamaguchi I, Sugishita Y, Goto K.

J Cardiovasc Pharmacol. 1993;22 Suppl 8:S336-8. doi: 10.1097/00005344-199322008-00088.

ORIGINAL RESEARCH

The ligand-receptor interactions of the endothelin systems are mediated by distinct “message” and “address” domains

Sakamoto A, Yanagisawa M, Sakurai T, Nakao K, Toyo-oka T, Yano M, Masaki T.

J Cardiovasc Pharmacol. 1993;22 Suppl 8:S113-6. doi: 10.1097/00005344-199322008-00031.

PUBLICATIONS研究業績

Pulmonary hypertension caused by congestive heart failure is ameliorated by long-term application of an endothelin receptor antagonist. Increased expression of endothelin-1 messenger ribonucleic acid and endothelin-1-like immunoreactivity in the lung in congestive heart failure in rats

Anticoagulant factor protein S inhibits the proliferation of rat astrocytes after injury

Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure. Marked increase in endothelin-1 production in the failing heart

Ultraviolet B irradiation increases endothelin-1 and endothelin receptor expression in cultured human keratinocytes

Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors

Altered production of endothelin-1 in the hypertrophied rat heart

Endothelin-1-induced downregulation of ETB receptor mRNA: participation of cAMP

Endothelin-1 activates mitogen-activated protein kinases through two independent signalling pathways in rat astrocytes

Molecular cloning of low-Ca(2+)-sensitive-type non-muscle alpha-actinin

Activin A stimulates mitogenesis in Swiss 3T3 fibroblasts without activation of mitogen-activated protein kinases

Endothelin-1 acts as an autocrine growth factor for normal human keratinocytes

Human endothelin receptor ETB. Amino acid sequence requirements for super stable complex formation with its ligand

Possible involvement of endothelin-1 in cardiac hypertrophy

Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension

Endothelins. Vascular actions and clinical implications

Increased production of endothelin-1 in the hypertrophied rat heart due to pressure overload

Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists

Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system

Altered expression of ETB-receptor mRNA in the lung of rats with pulmonary hypertension

The ligand-receptor interactions of the endothelin systems are mediated by distinct “message” and “address” domains