PUBLICATIONS研究業績

ORIGINAL RESEARCH

Structure and function of human prepro-orexin gene

Sakurai T, Moriguchi T, Furuya K, Kajiwara N, Nakamura T, Yanagisawa M, Goto K.

J Biol Chem. 1999 Jun 18;274(25):17771-6. doi: 10.1074/jbc.274.25.17771.

ORIGINAL RESEARCH

Distribution of orexin neurons in the adult rat brain

Nambu T, Sakurai T, Mizukami K, Hosoya Y, Yanagisawa M, Goto K.

Brain Res. 1999 May 8;827(1-2):243-60. doi: 10.1016/s0006-8993(99)01336-0.

ORIGINAL RESEARCH

Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia

Moriguchi T, Sakurai T, Nambu T, Yanagisawa M, Goto K.

Neurosci Lett. 1999 Apr 2;264(1-3):101-4. doi: 10.1016/s0304-3940(99)00177-9.

ORIGINAL RESEARCH

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Date Y, Ueta Y, Yamashita H, Yamaguchi H, Matsukura S, Kangawa K, Sakurai T, Yanagisawa M, Nakazato M.

Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):748-53. doi: 10.1073/pnas.96.2.748.

ORIGINAL RESEARCH

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, Kelly J, Tatro JB, Hoffman GE, Ollmann MM, Barsh GS, Sakurai T, Yanagisawa M, Elmquist JK.

J Comp Neurol. 1998 Dec 28;402(4):442-59.

ORIGINAL RESEARCH

Cloning and characterization of a novel endothelin receptor subtype in the avian class

Lecoin L, Sakurai T, Ngo MT, Abe Y, Yanagisawa M, Le Douarin NM.

Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3024-9. doi: 10.1073/pnas.95.6.3024.

ORIGINAL RESEARCH

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M.

Cell. 1998 Mar 6;92(5):1 page following 696. doi: 10.1016/s0092-8674(02)09256-5.

ORIGINAL RESEARCH

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M.

Cell. 1998 Feb 20;92(4):573-85. doi: 10.1016/s0092-8674(00)80949-6.

ORIGINAL RESEARCH

A novel aortic smooth muscle cell line obtained from p53 knock out mice expresses several differentiation characteristics

Ohmi K, Masuda T, Yamaguchi H, Sakurai T, Kudo Y, Katsuki M, Nonomura Y.

Biochem Biophys Res Commun. 1997 Sep 8;238(1):154-8. doi: 10.1006/bbrc.1997.7218.

ORIGINAL RESEARCH

Role of endothelin-1 in astrocyte responses after acute brain damage

Hama H, Kasuya Y, Sakurai T, Yamada G, Suzuki N, Masaki T, Goto K.

J Neurosci Res. 1997 Mar 15;47(6):590-602. doi: 10.1002/(sici)1097-4547(19970315)47:6<590::aid-jnr4>3.0.co;2-8.

ORIGINAL RESEARCH

Pulmonary hypertension caused by congestive heart failure is ameliorated by long-term application of an endothelin receptor antagonist. Increased expression of endothelin-1 messenger ribonucleic acid and endothelin-1-like immunoreactivity in the lung in congestive heart failure in rats

Sakai S, Miyauchi T, Sakurai T, Yamaguchi I, Kobayashi M, Goto K, Sugishita Y.

J Am Coll Cardiol. 1996 Nov 15;28(6):1580-8. doi: 10.1016/s0735-1097(96)00336-1.

ORIGINAL RESEARCH

Anticoagulant factor protein S inhibits the proliferation of rat astrocytes after injury

Tomobe YI, Hama H, Sakurai T, Fujimori A, Abe Y, Goto K.

Neurosci Lett. 1996 Aug 16;214(1):57-60. doi: 10.1016/0304-3940(96)12880-9.

ORIGINAL RESEARCH

Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure. Marked increase in endothelin-1 production in the failing heart

Sakai S, Miyauchi T, Sakurai T, Kasuya Y, Ihara M, Yamaguchi I, Goto K, Sugishita Y.

Circulation. 1996 Mar 15;93(6):1214-22. doi: 10.1161/01.cir.93.6.1214.

ORIGINAL RESEARCH

Ultraviolet B irradiation increases endothelin-1 and endothelin receptor expression in cultured human keratinocytes

Tsuboi R, Sato C, Oshita Y, Hama H, Sakurai T, Goto K, Ogawa H.

FEBS Lett. 1995 Sep 4;371(2):188-90. doi: 10.1016/0014-5793(95)00912-s.

ORIGINAL RESEARCH

Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors

Takigawa M, Sakurai T, Kasuya Y, Abe Y, Masaki T, Goto K.

Eur J Biochem. 1995 Feb 15;228(1):102-8. doi: 10.1111/j.1432-1033.1995.tb20236.x.

ORIGINAL RESEARCH

Altered production of endothelin-1 in the hypertrophied rat heart

Sakai S, Yorikane R, Miyauchi T, Sakurai T, Kasuya Y, Yamaguchi I, Sugishita Y, Goto K.

J Cardiovasc Pharmacol. 1995;26 Suppl 3:S452-5.

ORIGINAL RESEARCH

Endothelin-1-induced downregulation of ETB receptor mRNA: participation of cAMP

Asada S, Kasuya Y, Sakurai T, Masaki T, Goto K.

J Cardiovasc Pharmacol. 1995;26 Suppl 3:S272-5.

ORIGINAL RESEARCH

Endothelin-1 activates mitogen-activated protein kinases through two independent signalling pathways in rat astrocytes

Kasuya Y, Abe Y, Hama H, Sakurai T, Asada S, Masaki T, Goto K.

Biochem Biophys Res Commun. 1994 Nov 15;204(3):1325-33. doi: 10.1006/bbrc.1994.2608.

ORIGINAL RESEARCH

Molecular cloning of low-Ca(2+)-sensitive-type non-muscle alpha-actinin

Imamura M, Sakurai T, Ogawa Y, Ishikawa T, Goto K, Masaki T.

Eur J Biochem. 1994 Jul 15;223(2):395-401. doi: 10.1111/j.1432-1033.1994.tb19006.x.

ORIGINAL RESEARCH

Activin A stimulates mitogenesis in Swiss 3T3 fibroblasts without activation of mitogen-activated protein kinases

Sakurai T, Abe Y, Kasuya Y, Takuwa N, Shiba R, Yamashita T, Endo T, Goto K.

J Biol Chem. 1994 May 13;269(19):14118-22.