PUBLICATIONS研究業績

ORIGINAL RESEARCH

Effects of orexin on cultured porcine adrenal medullary and cortex cells

Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Goto K, Nakai T.

Regul Pept. 2002 Mar 15;104(1-3):125-30. doi: 10.1016/s0167-0115(01)00356-1.

ORIGINAL RESEARCH

Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Matsuzaki I, Sakurai T, Kunii K, Nakamura T, Yanagisawa M, Goto K.

Regul Pept. 2002 Mar 15;104(1-3):119-23. doi: 10.1016/s0167-0115(01)00355-x.

ORIGINAL RESEARCH

Orexins activate histaminergic neurons via the orexin 2 receptor

Yamanaka A, Tsujino N, Funahashi H, Honda K, Guan JL, Wang QP, Tominaga M, Goto K, Shioda S, Sakurai T.

Biochem Biophys Res Commun. 2002 Feb 1;290(4):1237-45. doi: 10.1006/bbrc.2001.6318.

ORIGINAL RESEARCH

Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus

Iqbal J, Pompolo S, Sakurai T, Clarke IJ.

J Neuroendocrinol. 2001 Dec;13(12):1033-41. doi: 10.1046/j.1365-2826.2001.00719.x.

ORIGINAL RESEARCH

Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus

Iqbal J, Pompolo S, Murakami T, Grouzmann E, Sakurai T, Meister B, Clarke IJ.

Brain Res. 2001 Nov 30;920(1-2):55-64. doi: 10.1016/s0006-8993(01)02932-8.

ORIGINAL RESEARCH

Orexin (hypocretin) neurons contain dynorphin

Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, Saper CB, Scammell TE.

J Neurosci. 2001 Oct 1;21(19):RC168. doi: 10.1523/JNEUROSCI.21-19-j0003.2001.

ORIGINAL RESEARCH

Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus

Muroya S, Uramura K, Sakurai T, Takigawa M, Yada T.

Neurosci Lett. 2001 Aug 31;309(3):165-8. doi: 10.1016/s0304-3940(01)02053-5.

ORIGINAL RESEARCH

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity

Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, Sakurai T.

Neuron. 2001 May;30(2):345-54. doi: 10.1016/s0896-6273(01)00293-8.

ORIGINAL RESEARCH

Functional analysis of five endothelin-B receptor mutations found in human Hirschsprung disease patients

Abe Y, Sakurai T, Yamada T, Nakamura T, Yanagisawa M, Goto K.

Biochem Biophys Res Commun. 2000 Aug 28;275(2):524-31. doi: 10.1006/bbrc.2000.3291.

ORIGINAL RESEARCH

[2-molecular neurobiology of orexins]

Sakurai T.

Seikagaku. 2000 Jun;72(6):455-60.

ORIGINAL RESEARCH

Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

Nakamura T, Uramura K, Nambu T, Yada T, Goto K, Yanagisawa M, Sakurai T.

Brain Res. 2000 Aug 4;873(1):181-7. doi: 10.1016/s0006-8993(00)02555-5.

ORIGINAL RESEARCH

Orexins suppress catecholamine synthesis and secretion in cultured PC12 cells

Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Ishii K, Goto K, Nakai T.

Biochem Biophys Res Commun. 2000 Aug 2;274(2):310-5. doi: 10.1006/bbrc.2000.3137.

ORIGINAL RESEARCH

Subtype-specific trafficking of endothelin receptors

Abe Y, Nakayama K, Yamanaka A, Sakurai T, Goto K.

J Biol Chem. 2000 Mar 24;275(12):8664-71. doi: 10.1074/jbc.275.12.8664.

ORIGINAL RESEARCH

Orexin-induced food intake involves neuropeptide Y pathway

Yamanaka A, Kunii K, Nambu T, Tsujino N, Sakai A, Matsuzaki I, Miwa Y, Goto K, Sakurai T.

Brain Res. 2000 Mar 24;859(2):404-9. doi: 10.1016/s0006-8993(00)02043-6.

ORIGINAL RESEARCH

Endothelin-1 concentration increases in the cerebrospinal fluid in cerebral vasospasm caused by subarachnoid hemorrhage

Suzuki K, Meguro K, Sakurai T, Saitoh Y, Takeuchi S, Nose T.

Surg Neurol. 2000 Feb;53(2):131-5. doi: 10.1016/s0090-3019(99)00179-2.

ORIGINAL RESEARCH

Pathophysiological role of endothelins in pulmonary microcirculatory disorders due to intestinal ischemia and reperfusion

Mitsuoka H, Unno N, Sakurai T, Kaneko H, Suzuki S, Konno H, Terakawa S, Nakamura S.

J Surg Res. 1999 Dec;87(2):143-51. doi: 10.1006/jsre.1999.5694.

ORIGINAL RESEARCH

Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight

Yamanaka A, Sakurai T, Katsumoto T, Yanagisawa M, Goto K.

Brain Res. 1999 Dec 4;849(1-2):248-52. doi: 10.1016/s0006-8993(99)01905-8.

ORIGINAL RESEARCH

Orexins and orexin receptors: implication in feeding behavior

Sakurai T.

Regul Pept. 1999 Nov 30;85(1):25-30. doi: 10.1016/s0167-0115(99)00076-2.

ORIGINAL RESEARCH

Structure, tissue distribution, and pharmacological characterization of Xenopus orexins

Shibahara M, Sakurai T, Nambu T, Takenouchi T, Iwaasa H, Egashira SI, Ihara M, Goto K.

Peptides. 1999;20(10):1169-76. doi: 10.1016/s0196-9781(99)00120-5.

ORIGINAL RESEARCH

Orexins/hypocretins regulate drinking behaviour

Kunii K, Yamanaka A, Nambu T, Matsuzaki I, Goto K, Sakurai T.

Brain Res. 1999 Sep 18;842(1):256-61. doi: 10.1016/s0006-8993(99)01884-3.