研究業績｜筑波大学国際統合睡眠医科学研究機構櫻井/平野研究室

ORIGINAL RESEARCH

Regulation of orexin neurons by the monoaminergic and cholinergic systems

Yamanaka A, Muraki Y, Tsujino N, Goto K, Sakurai T.

Biochem Biophys Res Commun. 2003 Mar 28;303(1):120-9. doi: 10.1016/s0006-291x(03)00299-7.

ORIGINAL RESEARCH

Ghrelin-induced food intake is mediated via the orexin pathway

Toshinai K, Date Y, Murakami N, Shimada M, Mondal MS, Shimbara T, Guan JL, Wang QP, Funahashi H, Sakurai T, Shioda S, Matsukura S, Kangawa K, Nakazato M.

Endocrinology. 2003 Apr;144(4):1506-12. doi: 10.1210/en.2002-220788.

ORIGINAL RESEARCH

A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats

Takeda K, Jin MB, Fujita M, Fukai M, Sakurai T, Nakayama M, Taniguchi M, Suzuki T, Shimamura T, Furukawa H, Todo S.

Surgery. 2003 Feb;133(2):197-206. doi: 10.1067/msy.2003.59.

ORIGINAL RESEARCH

Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system

Li Y, Gao XB, Sakurai T, van den Pol AN.

Neuron. 2002 Dec 19;36(6):1169-81. doi: 10.1016/s0896-6273(02)01132-7.

ORIGINAL RESEARCH

Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation

Guan JL, Uehara K, Lu S, Wang QP, Funahashi H, Sakurai T, Yanagizawa M, Shioda S.

Int J Obes Relat Metab Disord. 2002 Dec;26(12):1523-32. doi: 10.1038/sj.ijo.0802155.

ORIGINAL RESEARCH

Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways

Zhu Y, Yamanaka A, Kunii K, Tsujino N, Goto K, Sakurai T.

Physiol Behav. 2002 Nov;77(2-3):251-7. doi: 10.1016/s0031-9384(02)00843-0.

ORIGINAL RESEARCH

Activation of orexin neurones after noxious but not conditioned fear stimuli in rats

Zhu L, Onaka T, Sakurai T, Yada T.

Neuroreport. 2002 Jul 19;13(10):1351-3. doi: 10.1097/00001756-200207190-00027.

ORIGINAL RESEARCH

Roles of orexins in regulation of feeding and wakefulness

Sakurai T.

Neuroreport. 2002 Jun 12;13(8):987-95. doi: 10.1097/00001756-200206120-00001.

ORIGINAL RESEARCH

The human prepro-orexin gene regulatory region that activates gene expression in the lateral region and represses it in the medial regions of the hypothalamus

Moriguchi T, Sakurai T, Takahashi S, Goto K, Yamamoto M.

J Biol Chem. 2002 May 10;277(19):16985-92. doi: 10.1074/jbc.M107962200. Epub 2002 Feb 19.

ORIGINAL RESEARCH

Plasma orexin-A is lower in patients with narcolepsy

Higuchi S, Usui A, Murasaki M, Matsushita S, Nishioka N, Yoshino A, Matsui T, Muraoka H, Ishizuka Y, Kanba S, Sakurai T.

Neurosci Lett. 2002 Jan 25;318(2):61-4. doi: 10.1016/s0304-3940(01)02476-4.

ORIGINAL RESEARCH

Effects of orexin on cultured porcine adrenal medullary and cortex cells

Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Goto K, Nakai T.

Regul Pept. 2002 Mar 15;104(1-3):125-30. doi: 10.1016/s0167-0115(01)00356-1.

ORIGINAL RESEARCH

Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Matsuzaki I, Sakurai T, Kunii K, Nakamura T, Yanagisawa M, Goto K.

Regul Pept. 2002 Mar 15;104(1-3):119-23. doi: 10.1016/s0167-0115(01)00355-x.

ORIGINAL RESEARCH

Orexins activate histaminergic neurons via the orexin 2 receptor

Yamanaka A, Tsujino N, Funahashi H, Honda K, Guan JL, Wang QP, Tominaga M, Goto K, Shioda S, Sakurai T.

Biochem Biophys Res Commun. 2002 Feb 1;290(4):1237-45. doi: 10.1006/bbrc.2001.6318.

ORIGINAL RESEARCH

Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus

Iqbal J, Pompolo S, Sakurai T, Clarke IJ.

J Neuroendocrinol. 2001 Dec;13(12):1033-41. doi: 10.1046/j.1365-2826.2001.00719.x.

ORIGINAL RESEARCH

Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus

Iqbal J, Pompolo S, Murakami T, Grouzmann E, Sakurai T, Meister B, Clarke IJ.

Brain Res. 2001 Nov 30;920(1-2):55-64. doi: 10.1016/s0006-8993(01)02932-8.

ORIGINAL RESEARCH

Orexin (hypocretin) neurons contain dynorphin

Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, Saper CB, Scammell TE.

J Neurosci. 2001 Oct 1;21(19):RC168. doi: 10.1523/JNEUROSCI.21-19-j0003.2001.

ORIGINAL RESEARCH

Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus

Muroya S, Uramura K, Sakurai T, Takigawa M, Yada T.

Neurosci Lett. 2001 Aug 31;309(3):165-8. doi: 10.1016/s0304-3940(01)02053-5.

ORIGINAL RESEARCH

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity

Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, Sakurai T.

Neuron. 2001 May;30(2):345-54. doi: 10.1016/s0896-6273(01)00293-8.

ORIGINAL RESEARCH

Functional analysis of five endothelin-B receptor mutations found in human Hirschsprung disease patients

Abe Y, Sakurai T, Yamada T, Nakamura T, Yanagisawa M, Goto K.

Biochem Biophys Res Commun. 2000 Aug 28;275(2):524-31. doi: 10.1006/bbrc.2000.3291.

ORIGINAL RESEARCH

[2-molecular neurobiology of orexins]

Sakurai T.

Seikagaku. 2000 Jun;72(6):455-60.

PUBLICATIONS研究業績

Regulation of orexin neurons by the monoaminergic and cholinergic systems

Ghrelin-induced food intake is mediated via the orexin pathway

A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats

Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system

Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation

Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways

Activation of orexin neurones after noxious but not conditioned fear stimuli in rats

Roles of orexins in regulation of feeding and wakefulness

The human prepro-orexin gene regulatory region that activates gene expression in the lateral region and represses it in the medial regions of the hypothalamus

Plasma orexin-A is lower in patients with narcolepsy

Effects of orexin on cultured porcine adrenal medullary and cortex cells

Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Orexins activate histaminergic neurons via the orexin 2 receptor

Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus

Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus

Orexin (hypocretin) neurons contain dynorphin

Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity

Functional analysis of five endothelin-B receptor mutations found in human Hirschsprung disease patients

[2-molecular neurobiology of orexins]