PUBLICATIONS研究業績

Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice

Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, Muraki Y, Kageyama H, Kunita S, Takahashi S, Goto K, Koyama Y, Shioda S, Yanagisawa M.

Neuron. 2005 Apr 21;46(2):297-308. doi: 10.1016/j.neuron.2005.03.010.

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Reverse pharmacology of orexin: from an orphan GPCR to integrative physiology

Sakurai T.

Regul Pept. 2005 Mar 15;126(1-2):3-10. doi: 10.1016/j.regpep.2004.08.006.

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Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response

Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L.

J Neurosci. 2004 Dec 15;24(50):11439-48. doi: 10.1523/JNEUROSCI.3459-04.2004.

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Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice

Akiyama M, Yuasa T, Hayasaka N, Horikawa K, Sakurai T, Shibata S.

Eur J Neurosci. 2004 Dec;20(11):3054-62. doi: 10.1111/j.1460-9568.2004.03749.x.

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Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness

Mieda M, Williams SC, Sinton CM, Richardson JA, Sakurai T, Yanagisawa M.

J Neurosci. 2004 Nov 17;24(46):10493-501. doi: 10.1523/JNEUROSCI.3171-04.2004.

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[Regulation of endothelin-1 gene expression]

Hara J, Sakurai T.

Nihon Rinsho. 2004 Sep;62 Suppl 9:591-3.

[Endothelin receptor and intracellular signaling]

Hara J, Sakurai T.

Nihon Rinsho. 2004 Sep;62 Suppl 9:588-90.

Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor

Muraki Y, Yamanaka A, Tsujino N, Kilduff TS, Goto K, Sakurai T.

J Neurosci. 2004 Aug 11;24(32):7159-66. doi: 10.1523/JNEUROSCI.1027-04.2004.

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Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette’s syndrome comorbidity

Thompson MD, Comings DE, Abu-Ghazalah R, Jereseh Y, Lin L, Wade J, Sakurai T, Tokita S, Yoshida T, Tanaka H, Yanagisawa M, Burnham WM, Moldofsky H.

Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):69-75. doi: 10.1002/ajmg.b.30047.

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Behavioral state instability in orexin knock-out mice

Mochizuki T, Crocker A, McCormack S, Yanagisawa M, Sakurai T, Scammell TE.

J Neurosci. 2004 Jul 14;24(28):6291-300. doi: 10.1523/JNEUROSCI.0586-04.2004.

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Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat

Beuckmann CT, Sinton CM, Williams SC, Richardson JA, Hammer RE, Sakurai T, Yanagisawa M.

J Neurosci. 2004 May 5;24(18):4469-77. doi: 10.1523/JNEUROSCI.5560-03.2004.

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Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4649-54. doi: 10.1073/pnas.0400590101. Epub 2004 Mar 16.

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Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus

Muroya S, Funahashi H, Yamanaka A, Kohno D, Uramura K, Nambu T, Shibahara M, Kuramochi M, Takigawa M, Yanagisawa M, Sakurai T, Shioda S, Yada T.

Eur J Neurosci. 2004 Mar;19(6):1524-34. doi: 10.1111/j.1460-9568.2004.03255.x.

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USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney

Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T.

Biochem Biophys Res Commun. 2004 Apr 2;316(2):490-500. doi: 10.1016/j.bbrc.2004.02.075.

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Roles of orexins in the regulation of feeding and arousal

Sakurai T.

Sleep Med. 2002 Dec;3 Suppl 2:S3-9. doi: 10.1016/s1389-9457(02)00156-9.

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[Roles of biologically active peptide in regulation of feeding behavior and energy homeostasis]

Sakurai T.

Nihon Yakurigaku Zasshi. 2003 Sep;122(3):236-42. doi: 10.1254/fpj.122.236.

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Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins

Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, Goto K.

J Pharmacol Sci. 2003 Jul;92(3):259-66. doi: 10.1254/jphs.92.259.

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Orexin: a link between energy homeostasis and adaptive behaviour

Sakurai T.

Curr Opin Clin Nutr Metab Care. 2003 Jul;6(4):353-60. doi: 10.1097/01.mco.0000078995.96795.91.

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Hypothalamic orexin neurons regulate arousal according to energy balance in mice

Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami Ki, Sugiyama F, Goto K, Yanagisawa M, Sakurai T.

Neuron. 2003 Jun 5;38(5):701-13. doi: 10.1016/s0896-6273(03)00331-3.

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Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):6251-6. doi: 10.1073/pnas.0837789100. Epub 2003 Apr 28.

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