PUBLICATIONS研究業績

ORIGINAL RESEARCH

Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice

Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, Muraki Y, Kageyama H, Kunita S, Takahashi S, Goto K, Koyama Y, Shioda S, Yanagisawa M.

Neuron. 2005 Apr 21;46(2):297-308. doi: 10.1016/j.neuron.2005.03.010.

ORIGINAL RESEARCH

Reverse pharmacology of orexin: from an orphan GPCR to integrative physiology

Sakurai T.

Regul Pept. 2005 Mar 15;126(1-2):3-10. doi: 10.1016/j.regpep.2004.08.006.

ORIGINAL RESEARCH

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response

Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L.

J Neurosci. 2004 Dec 15;24(50):11439-48. doi: 10.1523/JNEUROSCI.3459-04.2004.

ORIGINAL RESEARCH

Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice

Akiyama M, Yuasa T, Hayasaka N, Horikawa K, Sakurai T, Shibata S.

Eur J Neurosci. 2004 Dec;20(11):3054-62. doi: 10.1111/j.1460-9568.2004.03749.x.

ORIGINAL RESEARCH

Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness

Mieda M, Williams SC, Sinton CM, Richardson JA, Sakurai T, Yanagisawa M.

J Neurosci. 2004 Nov 17;24(46):10493-501. doi: 10.1523/JNEUROSCI.3171-04.2004.

ORIGINAL RESEARCH

[Regulation of endothelin-1 gene expression]

Hara J, Sakurai T.

Nihon Rinsho. 2004 Sep;62 Suppl 9:591-3.

ORIGINAL RESEARCH

[Endothelin receptor and intracellular signaling]

Hara J, Sakurai T.

Nihon Rinsho. 2004 Sep;62 Suppl 9:588-90.

ORIGINAL RESEARCH

Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor

Muraki Y, Yamanaka A, Tsujino N, Kilduff TS, Goto K, Sakurai T.

J Neurosci. 2004 Aug 11;24(32):7159-66. doi: 10.1523/JNEUROSCI.1027-04.2004.

ORIGINAL RESEARCH

Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette’s syndrome comorbidity

Thompson MD, Comings DE, Abu-Ghazalah R, Jereseh Y, Lin L, Wade J, Sakurai T, Tokita S, Yoshida T, Tanaka H, Yanagisawa M, Burnham WM, Moldofsky H.

Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):69-75. doi: 10.1002/ajmg.b.30047.

ORIGINAL RESEARCH

Behavioral state instability in orexin knock-out mice

Mochizuki T, Crocker A, McCormack S, Yanagisawa M, Sakurai T, Scammell TE.

J Neurosci. 2004 Jul 14;24(28):6291-300. doi: 10.1523/JNEUROSCI.0586-04.2004.

ORIGINAL RESEARCH

Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat

Beuckmann CT, Sinton CM, Williams SC, Richardson JA, Hammer RE, Sakurai T, Yanagisawa M.

J Neurosci. 2004 May 5;24(18):4469-77. doi: 10.1523/JNEUROSCI.5560-03.2004.

ORIGINAL RESEARCH

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4649-54. doi: 10.1073/pnas.0400590101. Epub 2004 Mar 16.

ORIGINAL RESEARCH

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus

Muroya S, Funahashi H, Yamanaka A, Kohno D, Uramura K, Nambu T, Shibahara M, Kuramochi M, Takigawa M, Yanagisawa M, Sakurai T, Shioda S, Yada T.

Eur J Neurosci. 2004 Mar;19(6):1524-34. doi: 10.1111/j.1460-9568.2004.03255.x.

ORIGINAL RESEARCH

USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney

Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T.

Biochem Biophys Res Commun. 2004 Apr 2;316(2):490-500. doi: 10.1016/j.bbrc.2004.02.075.

ORIGINAL RESEARCH

Roles of orexins in the regulation of feeding and arousal

Sakurai T.

Sleep Med. 2002 Dec;3 Suppl 2:S3-9. doi: 10.1016/s1389-9457(02)00156-9.

ORIGINAL RESEARCH

[Roles of biologically active peptide in regulation of feeding behavior and energy homeostasis]

Sakurai T.

Nihon Yakurigaku Zasshi. 2003 Sep;122(3):236-42. doi: 10.1254/fpj.122.236.

ORIGINAL RESEARCH

Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins

Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, Goto K.

J Pharmacol Sci. 2003 Jul;92(3):259-66. doi: 10.1254/jphs.92.259.

ORIGINAL RESEARCH

Orexin: a link between energy homeostasis and adaptive behaviour

Sakurai T.

Curr Opin Clin Nutr Metab Care. 2003 Jul;6(4):353-60. doi: 10.1097/01.mco.0000078995.96795.91.

ORIGINAL RESEARCH

Hypothalamic orexin neurons regulate arousal according to energy balance in mice

Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami Ki, Sugiyama F, Goto K, Yanagisawa M, Sakurai T.

Neuron. 2003 Jun 5;38(5):701-13. doi: 10.1016/s0896-6273(03)00331-3.

ORIGINAL RESEARCH

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):6251-6. doi: 10.1073/pnas.0837789100. Epub 2003 Apr 28.