研究業績｜筑波大学国際統合睡眠医科学研究機構櫻井/平野研究室

ORIGINAL RESEARCH

Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette’s syndrome comorbidity

Thompson MD, Comings DE, Abu-Ghazalah R, Jereseh Y, Lin L, Wade J, Sakurai T, Tokita S, Yoshida T, Tanaka H, Yanagisawa M, Burnham WM, Moldofsky H.

Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):69-75. doi: 10.1002/ajmg.b.30047.

ORIGINAL RESEARCH

Behavioral state instability in orexin knock-out mice

Mochizuki T, Crocker A, McCormack S, Yanagisawa M, Sakurai T, Scammell TE.

J Neurosci. 2004 Jul 14;24(28):6291-300. doi: 10.1523/JNEUROSCI.0586-04.2004.

ORIGINAL RESEARCH

Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat

Beuckmann CT, Sinton CM, Williams SC, Richardson JA, Hammer RE, Sakurai T, Yanagisawa M.

J Neurosci. 2004 May 5;24(18):4469-77. doi: 10.1523/JNEUROSCI.5560-03.2004.

ORIGINAL RESEARCH

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4649-54. doi: 10.1073/pnas.0400590101. Epub 2004 Mar 16.

ORIGINAL RESEARCH

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus

Muroya S, Funahashi H, Yamanaka A, Kohno D, Uramura K, Nambu T, Shibahara M, Kuramochi M, Takigawa M, Yanagisawa M, Sakurai T, Shioda S, Yada T.

Eur J Neurosci. 2004 Mar;19(6):1524-34. doi: 10.1111/j.1460-9568.2004.03255.x.

ORIGINAL RESEARCH

USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney

Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T.

Biochem Biophys Res Commun. 2004 Apr 2;316(2):490-500. doi: 10.1016/j.bbrc.2004.02.075.

ORIGINAL RESEARCH

Roles of orexins in the regulation of feeding and arousal

Sakurai T.

Sleep Med. 2002 Dec;3 Suppl 2:S3-9. doi: 10.1016/s1389-9457(02)00156-9.

ORIGINAL RESEARCH

[Roles of biologically active peptide in regulation of feeding behavior and energy homeostasis]

Sakurai T.

Nihon Yakurigaku Zasshi. 2003 Sep;122(3):236-42. doi: 10.1254/fpj.122.236.

ORIGINAL RESEARCH

Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins

Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, Goto K.

J Pharmacol Sci. 2003 Jul;92(3):259-66. doi: 10.1254/jphs.92.259.

ORIGINAL RESEARCH

Orexin: a link between energy homeostasis and adaptive behaviour

Sakurai T.

Curr Opin Clin Nutr Metab Care. 2003 Jul;6(4):353-60. doi: 10.1097/01.mco.0000078995.96795.91.

ORIGINAL RESEARCH

Hypothalamic orexin neurons regulate arousal according to energy balance in mice

Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami Ki, Sugiyama F, Goto K, Yanagisawa M, Sakurai T.

Neuron. 2003 Jun 5;38(5):701-13. doi: 10.1016/s0896-6273(03)00331-3.

ORIGINAL RESEARCH

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):6251-6. doi: 10.1073/pnas.0837789100. Epub 2003 Apr 28.

ORIGINAL RESEARCH

Regulation of orexin neurons by the monoaminergic and cholinergic systems

Yamanaka A, Muraki Y, Tsujino N, Goto K, Sakurai T.

Biochem Biophys Res Commun. 2003 Mar 28;303(1):120-9. doi: 10.1016/s0006-291x(03)00299-7.

ORIGINAL RESEARCH

Ghrelin-induced food intake is mediated via the orexin pathway

Toshinai K, Date Y, Murakami N, Shimada M, Mondal MS, Shimbara T, Guan JL, Wang QP, Funahashi H, Sakurai T, Shioda S, Matsukura S, Kangawa K, Nakazato M.

Endocrinology. 2003 Apr;144(4):1506-12. doi: 10.1210/en.2002-220788.

ORIGINAL RESEARCH

A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats

Takeda K, Jin MB, Fujita M, Fukai M, Sakurai T, Nakayama M, Taniguchi M, Suzuki T, Shimamura T, Furukawa H, Todo S.

Surgery. 2003 Feb;133(2):197-206. doi: 10.1067/msy.2003.59.

ORIGINAL RESEARCH

Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system

Li Y, Gao XB, Sakurai T, van den Pol AN.

Neuron. 2002 Dec 19;36(6):1169-81. doi: 10.1016/s0896-6273(02)01132-7.

ORIGINAL RESEARCH

Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation

Guan JL, Uehara K, Lu S, Wang QP, Funahashi H, Sakurai T, Yanagizawa M, Shioda S.

Int J Obes Relat Metab Disord. 2002 Dec;26(12):1523-32. doi: 10.1038/sj.ijo.0802155.

ORIGINAL RESEARCH

Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways

Zhu Y, Yamanaka A, Kunii K, Tsujino N, Goto K, Sakurai T.

Physiol Behav. 2002 Nov;77(2-3):251-7. doi: 10.1016/s0031-9384(02)00843-0.

ORIGINAL RESEARCH

Activation of orexin neurones after noxious but not conditioned fear stimuli in rats

Zhu L, Onaka T, Sakurai T, Yada T.

Neuroreport. 2002 Jul 19;13(10):1351-3. doi: 10.1097/00001756-200207190-00027.

ORIGINAL RESEARCH

Roles of orexins in regulation of feeding and wakefulness

Sakurai T.

Neuroreport. 2002 Jun 12;13(8):987-95. doi: 10.1097/00001756-200206120-00001.

PUBLICATIONS研究業績

Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette’s syndrome comorbidity

Behavioral state instability in orexin knock-out mice

Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus

USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney

Roles of orexins in the regulation of feeding and arousal

[Roles of biologically active peptide in regulation of feeding behavior and energy homeostasis]

Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins

Orexin: a link between energy homeostasis and adaptive behaviour

Hypothalamic orexin neurons regulate arousal according to energy balance in mice

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

Regulation of orexin neurons by the monoaminergic and cholinergic systems

Ghrelin-induced food intake is mediated via the orexin pathway

A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats

Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system

Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation

Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways

Activation of orexin neurones after noxious but not conditioned fear stimuli in rats

Roles of orexins in regulation of feeding and wakefulness