研究業績｜筑波大学国際統合睡眠医科学研究機構櫻井/平野研究室

ORIGINAL RESEARCH

[Roles of biologically active peptide in regulation of feeding behavior and energy homeostasis]

Sakurai T.

Nihon Yakurigaku Zasshi. 2003 Sep;122(3):236-42. doi: 10.1254/fpj.122.236.

ORIGINAL RESEARCH

Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins

Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, Goto K.

J Pharmacol Sci. 2003 Jul;92(3):259-66. doi: 10.1254/jphs.92.259.

ORIGINAL RESEARCH

Orexin: a link between energy homeostasis and adaptive behaviour

Sakurai T.

Curr Opin Clin Nutr Metab Care. 2003 Jul;6(4):353-60. doi: 10.1097/01.mco.0000078995.96795.91.

ORIGINAL RESEARCH

Hypothalamic orexin neurons regulate arousal according to energy balance in mice

Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami Ki, Sugiyama F, Goto K, Yanagisawa M, Sakurai T.

Neuron. 2003 Jun 5;38(5):701-13. doi: 10.1016/s0896-6273(03)00331-3.

ORIGINAL RESEARCH

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):6251-6. doi: 10.1073/pnas.0837789100. Epub 2003 Apr 28.

ORIGINAL RESEARCH

Regulation of orexin neurons by the monoaminergic and cholinergic systems

Yamanaka A, Muraki Y, Tsujino N, Goto K, Sakurai T.

Biochem Biophys Res Commun. 2003 Mar 28;303(1):120-9. doi: 10.1016/s0006-291x(03)00299-7.

ORIGINAL RESEARCH

Ghrelin-induced food intake is mediated via the orexin pathway

Toshinai K, Date Y, Murakami N, Shimada M, Mondal MS, Shimbara T, Guan JL, Wang QP, Funahashi H, Sakurai T, Shioda S, Matsukura S, Kangawa K, Nakazato M.

Endocrinology. 2003 Apr;144(4):1506-12. doi: 10.1210/en.2002-220788.

ORIGINAL RESEARCH

A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats

Takeda K, Jin MB, Fujita M, Fukai M, Sakurai T, Nakayama M, Taniguchi M, Suzuki T, Shimamura T, Furukawa H, Todo S.

Surgery. 2003 Feb;133(2):197-206. doi: 10.1067/msy.2003.59.

ORIGINAL RESEARCH

Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system

Li Y, Gao XB, Sakurai T, van den Pol AN.

Neuron. 2002 Dec 19;36(6):1169-81. doi: 10.1016/s0896-6273(02)01132-7.

ORIGINAL RESEARCH

Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation

Guan JL, Uehara K, Lu S, Wang QP, Funahashi H, Sakurai T, Yanagizawa M, Shioda S.

Int J Obes Relat Metab Disord. 2002 Dec;26(12):1523-32. doi: 10.1038/sj.ijo.0802155.

ORIGINAL RESEARCH

Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways

Zhu Y, Yamanaka A, Kunii K, Tsujino N, Goto K, Sakurai T.

Physiol Behav. 2002 Nov;77(2-3):251-7. doi: 10.1016/s0031-9384(02)00843-0.

ORIGINAL RESEARCH

Activation of orexin neurones after noxious but not conditioned fear stimuli in rats

Zhu L, Onaka T, Sakurai T, Yada T.

Neuroreport. 2002 Jul 19;13(10):1351-3. doi: 10.1097/00001756-200207190-00027.

ORIGINAL RESEARCH

Roles of orexins in regulation of feeding and wakefulness

Sakurai T.

Neuroreport. 2002 Jun 12;13(8):987-95. doi: 10.1097/00001756-200206120-00001.

ORIGINAL RESEARCH

The human prepro-orexin gene regulatory region that activates gene expression in the lateral region and represses it in the medial regions of the hypothalamus

Moriguchi T, Sakurai T, Takahashi S, Goto K, Yamamoto M.

J Biol Chem. 2002 May 10;277(19):16985-92. doi: 10.1074/jbc.M107962200. Epub 2002 Feb 19.

ORIGINAL RESEARCH

Plasma orexin-A is lower in patients with narcolepsy

Higuchi S, Usui A, Murasaki M, Matsushita S, Nishioka N, Yoshino A, Matsui T, Muraoka H, Ishizuka Y, Kanba S, Sakurai T.

Neurosci Lett. 2002 Jan 25;318(2):61-4. doi: 10.1016/s0304-3940(01)02476-4.

ORIGINAL RESEARCH

Effects of orexin on cultured porcine adrenal medullary and cortex cells

Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Goto K, Nakai T.

Regul Pept. 2002 Mar 15;104(1-3):125-30. doi: 10.1016/s0167-0115(01)00356-1.

ORIGINAL RESEARCH

Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Matsuzaki I, Sakurai T, Kunii K, Nakamura T, Yanagisawa M, Goto K.

Regul Pept. 2002 Mar 15;104(1-3):119-23. doi: 10.1016/s0167-0115(01)00355-x.

ORIGINAL RESEARCH

Orexins activate histaminergic neurons via the orexin 2 receptor

Yamanaka A, Tsujino N, Funahashi H, Honda K, Guan JL, Wang QP, Tominaga M, Goto K, Shioda S, Sakurai T.

Biochem Biophys Res Commun. 2002 Feb 1;290(4):1237-45. doi: 10.1006/bbrc.2001.6318.

ORIGINAL RESEARCH

Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus

Iqbal J, Pompolo S, Sakurai T, Clarke IJ.

J Neuroendocrinol. 2001 Dec;13(12):1033-41. doi: 10.1046/j.1365-2826.2001.00719.x.

ORIGINAL RESEARCH

Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus

Iqbal J, Pompolo S, Murakami T, Grouzmann E, Sakurai T, Meister B, Clarke IJ.

Brain Res. 2001 Nov 30;920(1-2):55-64. doi: 10.1016/s0006-8993(01)02932-8.

PUBLICATIONS研究業績

[Roles of biologically active peptide in regulation of feeding behavior and energy homeostasis]

Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins

Orexin: a link between energy homeostasis and adaptive behaviour

Hypothalamic orexin neurons regulate arousal according to energy balance in mice

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

Regulation of orexin neurons by the monoaminergic and cholinergic systems

Ghrelin-induced food intake is mediated via the orexin pathway

A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats

Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system

Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation

Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways

Activation of orexin neurones after noxious but not conditioned fear stimuli in rats

Roles of orexins in regulation of feeding and wakefulness

The human prepro-orexin gene regulatory region that activates gene expression in the lateral region and represses it in the medial regions of the hypothalamus

Plasma orexin-A is lower in patients with narcolepsy

Effects of orexin on cultured porcine adrenal medullary and cortex cells

Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Orexins activate histaminergic neurons via the orexin 2 receptor

Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus

Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus