PUBLICATIONS研究業績

Decreased intake of sucrose solutions in orexin knockout mice

Matsuo E, Mochizuki A, Nakayama K, Nakamura S, Yamamoto T, Shioda S, Sakurai T, Yanagisawa M, Shiuchi T, Minokoshi Y, Inoue T.

J Mol Neurosci. 2011 Feb;43(2):217-24. doi: 10.1007/s12031-010-9475-1. Epub 2010 Nov 18.

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[Orexin (ORX)]

Sakurai T.

Nihon Rinsho. 2010 Jul;68 Suppl 7:633-6.

Orexin neurons are indispensable for stress-induced thermogenesis in mice

Zhang W, Sunanaga J, Takahashi Y, Mori T, Sakurai T, Kanmura Y, Kuwaki T.

J Physiol. 2010 Nov 1;588(Pt 21):4117-29. doi: 10.1113/jphysiol.2010.195099. Epub 2010 Aug 31.

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Ectopic overexpression of orexin alters sleep/wakefulness states and muscle tone regulation during REM sleep in mice

Willie JT, Takahira H, Shibahara M, Hara J, Nomiyama M, Yanagisawa M, Sakurai T.

J Mol Neurosci. 2011 Feb;43(2):155-61. doi: 10.1007/s12031-010-9437-7. Epub 2010 Aug 14.

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The orexin system: roles in sleep/wake regulation

Sakurai T, Mieda M, Tsujino N.

Ann N Y Acad Sci. 2010 Jul;1200:149-61. doi: 10.1111/j.1749-6632.2010.05513.x.

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Activation of bombesin receptor subtype-3 influences activity of orexin neurons by both direct and indirect pathways

Furutani N, Hondo M, Tsujino N, Sakurai T.

J Mol Neurosci. 2010 Sep;42(1):106-11. doi: 10.1007/s12031-010-9382-5. Epub 2010 May 14.

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Circadian characteristics of mice depleted with GPR7

Uchio N, Doi M, Matsuo M, Yamazaki F, Mizoro Y, Hondo M, Sakurai T, Okamura H.

Biomed Res. 2009 Dec;30(6):357-64. doi: 10.2220/biomedres.30.357.

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Characterization of sleep-wake patterns in a novel transgenic mouse line overexpressing human prepro-orexin/hypocretin

Mäkelä KA, Wigren HK, Zant JC, Sakurai T, Alhonen L, Kostin A, Porkka-Heiskanen T, Herzig KH.

Acta Physiol (Oxf). 2010 Mar;198(3):237-49. doi: 10.1111/j.1748-1716.2009.02068.x. Epub 2009 Dec 10.

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Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system

Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y.

Cell Metab. 2009 Dec;10(6):466-80. doi: 10.1016/j.cmet.2009.09.013.

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Monoaminergic neuronal changes in orexin deficient mice

Mori T, Ito S, Kuwaki T, Yanagisawa M, Sakurai T, Sawaguchi T.

Neuropharmacology. 2010 Mar-Apr;58(4-5):826-32. doi: 10.1016/j.neuropharm.2009.08.009. Epub 2009 Aug 22.

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Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states

Hondo M, Nagai K, Ohno K, Kisanuki Y, Willie JT, Watanabe T, Yanagisawa M, Sakurai T.

Acta Physiol (Oxf). 2010 Mar;198(3):287-94. doi: 10.1111/j.1748-1716.2009.02032.x. Epub 2009 Aug 20.

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Integrative physiology of orexins and orexin receptors

Mieda M, Sakurai T.

CNS Neurol Disord Drug Targets. 2009 Aug;8(4):281-95. doi: 10.2174/187152709788921663.

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Attenuated phrenic long-term facilitation in orexin neuron-ablated mice

Toyama S, Sakurai T, Tatsumi K, Kuwaki T.

Respir Physiol Neurobiol. 2009 Sep 30;168(3):295-302. doi: 10.1016/j.resp.2009.07.025. Epub 2009 Aug 5.

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Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system

Tsujino N, Sakurai T.

Pharmacol Rev. 2009 Jun;61(2):162-76. doi: 10.1124/pr.109.001321.

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Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis

Zhang W, Zhang N, Sakurai T, Kuwaki T.

Brain Res. 2009 Mar 25;1262:25-37. doi: 10.1016/j.brainres.2009.01.022. Epub 2009 Jan 27.

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Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons

Hara J, Gerashchenko D, Wisor JP, Sakurai T, Xie X, Kilduff TS.

J Neurosci. 2009 Mar 25;29(12):3705-14. doi: 10.1523/JNEUROSCI.0431-09.2009.

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Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture

Matsuki T, Nomiyama M, Takahira H, Hirashima N, Kunita S, Takahashi S, Yagami K, Kilduff TS, Bettler B, Yanagisawa M, Sakurai T.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4459-64. doi: 10.1073/pnas.0811126106. Epub 2009 Feb 25.

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Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B

Irukayama-Tomobe Y, Tanaka H, Yokomizo T, Hashidate-Yoshida T, Yanagisawa M, Sakurai T.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4. doi: 10.1073/pnas.0811844106. Epub 2009 Feb 23.

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IGFBP3 colocalizes with and regulates hypocretin (orexin)

Honda M, Eriksson KS, Zhang S, Tanaka S, Lin L, Salehi A, Hesla PE, Maehlen J, Gaus SE, Yanagisawa M, Sakurai T, Taheri S, Tsuchiya K, Honda Y, Mignot E.

PLoS One. 2009;4(1):e4254. doi: 10.1371/journal.pone.0004254. Epub 2009 Jan 22.

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Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity

Funato H, Tsai AL, Willie JT, Kisanuki Y, Williams SC, Sakurai T, Yanagisawa M.

Cell Metab. 2009 Jan 7;9(1):64-76. doi: 10.1016/j.cmet.2008.10.010.

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