PUBLICATIONS研究業績

ORIGINAL RESEARCH

Monoaminergic neuronal changes in orexin deficient mice

Mori T, Ito S, Kuwaki T, Yanagisawa M, Sakurai T, Sawaguchi T.

Neuropharmacology. 2010 Mar-Apr;58(4-5):826-32. doi: 10.1016/j.neuropharm.2009.08.009. Epub 2009 Aug 22.

ORIGINAL RESEARCH

Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states

Hondo M, Nagai K, Ohno K, Kisanuki Y, Willie JT, Watanabe T, Yanagisawa M, Sakurai T.

Acta Physiol (Oxf). 2010 Mar;198(3):287-94. doi: 10.1111/j.1748-1716.2009.02032.x. Epub 2009 Aug 20.

ORIGINAL RESEARCH

Integrative physiology of orexins and orexin receptors

Mieda M, Sakurai T.

CNS Neurol Disord Drug Targets. 2009 Aug;8(4):281-95. doi: 10.2174/187152709788921663.

ORIGINAL RESEARCH

Attenuated phrenic long-term facilitation in orexin neuron-ablated mice

Toyama S, Sakurai T, Tatsumi K, Kuwaki T.

Respir Physiol Neurobiol. 2009 Sep 30;168(3):295-302. doi: 10.1016/j.resp.2009.07.025. Epub 2009 Aug 5.

ORIGINAL RESEARCH

Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system

Tsujino N, Sakurai T.

Pharmacol Rev. 2009 Jun;61(2):162-76. doi: 10.1124/pr.109.001321.

ORIGINAL RESEARCH

Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis

Zhang W, Zhang N, Sakurai T, Kuwaki T.

Brain Res. 2009 Mar 25;1262:25-37. doi: 10.1016/j.brainres.2009.01.022. Epub 2009 Jan 27.

ORIGINAL RESEARCH

Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons

Hara J, Gerashchenko D, Wisor JP, Sakurai T, Xie X, Kilduff TS.

J Neurosci. 2009 Mar 25;29(12):3705-14. doi: 10.1523/JNEUROSCI.0431-09.2009.

ORIGINAL RESEARCH

Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture

Matsuki T, Nomiyama M, Takahira H, Hirashima N, Kunita S, Takahashi S, Yagami K, Kilduff TS, Bettler B, Yanagisawa M, Sakurai T.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4459-64. doi: 10.1073/pnas.0811126106. Epub 2009 Feb 25.

ORIGINAL RESEARCH

Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B

Irukayama-Tomobe Y, Tanaka H, Yokomizo T, Hashidate-Yoshida T, Yanagisawa M, Sakurai T.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4. doi: 10.1073/pnas.0811844106. Epub 2009 Feb 23.

ORIGINAL RESEARCH

IGFBP3 colocalizes with and regulates hypocretin (orexin)

Honda M, Eriksson KS, Zhang S, Tanaka S, Lin L, Salehi A, Hesla PE, Maehlen J, Gaus SE, Yanagisawa M, Sakurai T, Taheri S, Tsuchiya K, Honda Y, Mignot E.

PLoS One. 2009;4(1):e4254. doi: 10.1371/journal.pone.0004254. Epub 2009 Jan 22.

ORIGINAL RESEARCH

Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity

Funato H, Tsai AL, Willie JT, Kisanuki Y, Williams SC, Sakurai T, Yanagisawa M.

Cell Metab. 2009 Jan 7;9(1):64-76. doi: 10.1016/j.cmet.2008.10.010.

ORIGINAL RESEARCH

New developments in sleep research: molecular genetics, gene expression, and systems neurobiology

Kilduff TS, Lein ES, de la Iglesia H, Sakurai T, Fu YH, Shaw P.

J Neurosci. 2008 Nov 12;28(46):11814-8. doi: 10.1523/JNEUROSCI.3768-08.2008.

ORIGINAL RESEARCH

Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice

Liu M, Thankachan S, Kaur S, Begum S, Blanco-Centurion C, Sakurai T, Yanagisawa M, Neve R, Shiromani PJ.

Eur J Neurosci. 2008 Oct;28(7):1382-93. doi: 10.1111/j.1460-9568.2008.06446.x.

ORIGINAL RESEARCH

Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities

Aikawa S, Ishii M, Yanagisawa M, Sakakibara Y, Sakurai T.

Regul Pept. 2008 Nov 29;151(1-3):147-52. doi: 10.1016/j.regpep.2008.08.001. Epub 2008 Sep 10.

ORIGINAL RESEARCH

Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy

Mishima K, Fujiki N, Yoshida Y, Sakurai T, Honda M, Mignot E, Nishino S.

Sleep. 2008 Aug;31(8):1119-26.

ORIGINAL RESEARCH

Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia

Xie X, Wisor JP, Hara J, Crowder TL, LeWinter R, Khroyan TV, Yamanaka A, Diano S, Horvath TL, Sakurai T, Toll L, Kilduff TS.

J Clin Invest. 2008 Jul;118(7):2471-81. doi: 10.1172/JCI35115.

ORIGINAL RESEARCH

Cholinergic regulation of orexin/hypocretin neurons through M(3) muscarinic receptor in mice

Ohno K, Hondo M, Sakurai T.

J Pharmacol Sci. 2008 Mar;106(3):485-91. doi: 10.1254/jphs.fp0071986. Epub 2008 Mar 12.

ORIGINAL RESEARCH

Entrainment of temperature and activity rhythms to restricted feeding in orexin knock out mice

Kaur S, Thankachan S, Begum S, Blanco-Centurion C, Sakurai T, Yanagisawa M, Shiromani PJ.

Brain Res. 2008 Apr 18;1205:47-54. doi: 10.1016/j.brainres.2008.02.026. Epub 2008 Feb 21.

ORIGINAL RESEARCH

Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice

Tsuneki H, Murata S, Anzawa Y, Soeda Y, Tokai E, Wada T, Kimura I, Yanagisawa M, Sakurai T, Sasaoka T.

Diabetologia. 2008 Apr;51(4):657-67. doi: 10.1007/s00125-008-0929-8. Epub 2008 Feb 7.

ORIGINAL RESEARCH

Orexins and orexin receptors: from molecules to integrative physiology

Matsuki T, Sakurai T.

Results Probl Cell Differ. 2008;46:27-55. doi: 10.1007/400_2007_047.