PUBLICATIONS研究業績

REVIEW

Overview of orexin/hypocretin system

Mieda M, Sakurai T.

Prog Brain Res. 2012;198:5-14. doi: 10.1016/B978-0-444-59489-1.00002-1.

REVIEW

[Hypothalamic neuropeptides implicated in the regulation of sleep/wakefulness states]

Sakurai T.

Brain Nerve. 2012 Jun;64(6):629-37.

ORIGINAL RESEARCH

A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions

Watanabe N, Wada M, Irukayama-Tomobe Y, Ogata Y, Tsujino N, Suzuki M, Furutani N, Sakurai T, Yamamoto M.

PLoS One. 2012;7(4):e35390. doi: 10.1371/journal.pone.0035390. Epub 2012 Apr 24.

ORIGINAL RESEARCH

[Connectomics of orexin-producing neurons: analysis using mouse models]

Sakurai T.

Nihon Shinkei Seishin Yakurigaku Zasshi. 2011 Nov;31(5-6):223-9.

ORIGINAL RESEARCH

Bmal1 in the nervous system is essential for normal adaptation of circadian locomotor activity and food intake to periodic feeding

Mieda M, Sakurai T.

J Neurosci. 2011 Oct 26;31(43):15391-6. doi: 10.1523/JNEUROSCI.2801-11.2011.

ORIGINAL RESEARCH

Orexin neurons receive glycinergic innervations

Hondo M, Furutani N, Yamasaki M, Watanabe M, Sakurai T.

PLoS One. 2011;6(9):e25076. doi: 10.1371/journal.pone.0025076. Epub 2011 Sep 16.

ORIGINAL RESEARCH

Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

Sasaki K, Suzuki M, Mieda M, Tsujino N, Roth B, Sakurai T.

PLoS One. 2011;6(5):e20360. doi: 10.1371/journal.pone.0020360. Epub 2011 May 27.

ORIGINAL RESEARCH

Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal

Sakurai T, Mieda M.

Trends Pharmacol Sci. 2011 Aug;32(8):451-62. doi: 10.1016/j.tips.2011.03.007. Epub 2011 May 11.

ORIGINAL RESEARCH

Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep

Mieda M, Hasegawa E, Kisanuki YY, Sinton CM, Yanagisawa M, Sakurai T.

J Neurosci. 2011 Apr 27;31(17):6518-26. doi: 10.1523/JNEUROSCI.6506-10.2011.

ORIGINAL RESEARCH

Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice

Liu M, Blanco-Centurion C, Konadhode R, Begum S, Pelluru D, Gerashchenko D, Sakurai T, Yanagisawa M, van den Pol AN, Shiromani PJ.

J Neurosci. 2011 Apr 20;31(16):6028-40. doi: 10.1523/JNEUROSCI.6069-10.2011.

ORIGINAL RESEARCH

Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory

Nagata-Kuroiwa R, Furutani N, Hara J, Hondo M, Ishii M, Abe T, Mieda M, Tsujino N, Motoike T, Yanagawa Y, Kuwaki T, Yamamoto M, Yanagisawa M, Sakurai T.

PLoS One. 2011 Feb 24;6(2):e16972. doi: 10.1371/journal.pone.0016972.

ORIGINAL RESEARCH

Decreased intake of sucrose solutions in orexin knockout mice

Matsuo E, Mochizuki A, Nakayama K, Nakamura S, Yamamoto T, Shioda S, Sakurai T, Yanagisawa M, Shiuchi T, Minokoshi Y, Inoue T.

J Mol Neurosci. 2011 Feb;43(2):217-24. doi: 10.1007/s12031-010-9475-1. Epub 2010 Nov 18.

ORIGINAL RESEARCH

[Orexin (ORX)]

Sakurai T.

Nihon Rinsho. 2010 Jul;68 Suppl 7:633-6.

ORIGINAL RESEARCH

Orexin neurons are indispensable for stress-induced thermogenesis in mice

Zhang W, Sunanaga J, Takahashi Y, Mori T, Sakurai T, Kanmura Y, Kuwaki T.

J Physiol. 2010 Nov 1;588(Pt 21):4117-29. doi: 10.1113/jphysiol.2010.195099. Epub 2010 Aug 31.

ORIGINAL RESEARCH

Ectopic overexpression of orexin alters sleep/wakefulness states and muscle tone regulation during REM sleep in mice

Willie JT, Takahira H, Shibahara M, Hara J, Nomiyama M, Yanagisawa M, Sakurai T.

J Mol Neurosci. 2011 Feb;43(2):155-61. doi: 10.1007/s12031-010-9437-7. Epub 2010 Aug 14.

ORIGINAL RESEARCH

The orexin system: roles in sleep/wake regulation

Sakurai T, Mieda M, Tsujino N.

Ann N Y Acad Sci. 2010 Jul;1200:149-61. doi: 10.1111/j.1749-6632.2010.05513.x.

ORIGINAL RESEARCH

Activation of bombesin receptor subtype-3 influences activity of orexin neurons by both direct and indirect pathways

Furutani N, Hondo M, Tsujino N, Sakurai T.

J Mol Neurosci. 2010 Sep;42(1):106-11. doi: 10.1007/s12031-010-9382-5. Epub 2010 May 14.

ORIGINAL RESEARCH

Circadian characteristics of mice depleted with GPR7

Uchio N, Doi M, Matsuo M, Yamazaki F, Mizoro Y, Hondo M, Sakurai T, Okamura H.

Biomed Res. 2009 Dec;30(6):357-64. doi: 10.2220/biomedres.30.357.

ORIGINAL RESEARCH

Characterization of sleep-wake patterns in a novel transgenic mouse line overexpressing human prepro-orexin/hypocretin

Mäkelä KA, Wigren HK, Zant JC, Sakurai T, Alhonen L, Kostin A, Porkka-Heiskanen T, Herzig KH.

Acta Physiol (Oxf). 2010 Mar;198(3):237-49. doi: 10.1111/j.1748-1716.2009.02068.x. Epub 2009 Dec 10.

ORIGINAL RESEARCH

Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system

Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y.

Cell Metab. 2009 Dec;10(6):466-80. doi: 10.1016/j.cmet.2009.09.013.