PUBLICATIONS研究業績

Orexin deficiency and narcolepsy

Sakurai T.

Curr Opin Neurobiol. 2013 Oct;23(5):760-6. doi: 10.1016/j.conb.2013.04.007. Epub 2013 May 7.

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Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states

Furutani N, Hondo M, Kageyama H, Tsujino N, Mieda M, Yanagisawa M, Shioda S, Sakurai T.

PLoS One. 2013 Apr 19;8(4):e62391. doi: 10.1371/journal.pone.0062391. Print 2013.

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Role of orexin in modulating arousal, feeding, and motivation

Tsujino N, Sakurai T.

Front Behav Neurosci. 2013 Apr 18;7:28. doi: 10.3389/fnbeh.2013.00028. eCollection 2013.

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Hypocretin/orexin neurons contribute to hippocampus-dependent social memory and synaptic plasticity in mice

Yang L, Zou B, Xiong X, Pascual C, Xie J, Malik A, Xie J, Sakurai T, Xie XS.

J Neurosci. 2013 Mar 20;33(12):5275-84. doi: 10.1523/JNEUROSCI.3200-12.2013.

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NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion

Sakurai T.

Front Endocrinol (Lausanne). 2013 Mar 18;4:23. doi: 10.3389/fendo.2013.00023. eCollection 2013.

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Hypothalamic orexin prevents hepatic insulin resistance induced by social defeat stress in mice

Tsuneki H, Tokai E, Sugawara C, Wada T, Sakurai T, Sasaoka T.

Neuropeptides. 2013 Jun;47(3):213-9. doi: 10.1016/j.npep.2013.02.002. Epub 2013 Mar 16.

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Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status

Mieda M, Sakurai T.

CNS Drugs. 2013 Feb;27(2):83-90. doi: 10.1007/s40263-012-0036-8.

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Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation

Xiong X, White RE, Xu L, Yang L, Sun X, Zou B, Pascual C, Sakurai T, Giffard RG, Xie XS.

Stroke. 2013 Mar;44(3):764-70. doi: 10.1161/STROKEAHA.112.681700. Epub 2013 Jan 24.

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Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ

Schöne C, Cao ZF, Apergis-Schoute J, Adamantidis A, Sakurai T, Burdakov D.

J Neurosci. 2012 Sep 5;32(36):12437-43. doi: 10.1523/JNEUROSCI.0706-12.2012.

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[Circadian rhythm of leptin, orexin and ghrelin]

Tsujino N, Sakurai T.

Nihon Rinsho. 2012 Jul;70(7):1121-5.

Overview of orexin/hypocretin system

Mieda M, Sakurai T.

Prog Brain Res. 2012;198:5-14. doi: 10.1016/B978-0-444-59489-1.00002-1.

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[Hypothalamic neuropeptides implicated in the regulation of sleep/wakefulness states]

Sakurai T.

Brain Nerve. 2012 Jun;64(6):629-37.

A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions

Watanabe N, Wada M, Irukayama-Tomobe Y, Ogata Y, Tsujino N, Suzuki M, Furutani N, Sakurai T, Yamamoto M.

PLoS One. 2012;7(4):e35390. doi: 10.1371/journal.pone.0035390. Epub 2012 Apr 24.

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[Connectomics of orexin-producing neurons: analysis using mouse models]

Sakurai T.

Nihon Shinkei Seishin Yakurigaku Zasshi. 2011 Nov;31(5-6):223-9.

Bmal1 in the nervous system is essential for normal adaptation of circadian locomotor activity and food intake to periodic feeding

Mieda M, Sakurai T.

J Neurosci. 2011 Oct 26;31(43):15391-6. doi: 10.1523/JNEUROSCI.2801-11.2011.

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Orexin neurons receive glycinergic innervations

Hondo M, Furutani N, Yamasaki M, Watanabe M, Sakurai T.

PLoS One. 2011;6(9):e25076. doi: 10.1371/journal.pone.0025076. Epub 2011 Sep 16.

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Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

Sasaki K, Suzuki M, Mieda M, Tsujino N, Roth B, Sakurai T.

PLoS One. 2011;6(5):e20360. doi: 10.1371/journal.pone.0020360. Epub 2011 May 27.

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Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal

Sakurai T, Mieda M.

Trends Pharmacol Sci. 2011 Aug;32(8):451-62. doi: 10.1016/j.tips.2011.03.007. Epub 2011 May 11.

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Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep

Mieda M, Hasegawa E, Kisanuki YY, Sinton CM, Yanagisawa M, Sakurai T.

J Neurosci. 2011 Apr 27;31(17):6518-26. doi: 10.1523/JNEUROSCI.6506-10.2011.

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Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice

Liu M, Blanco-Centurion C, Konadhode R, Begum S, Pelluru D, Gerashchenko D, Sakurai T, Yanagisawa M, van den Pol AN, Shiromani PJ.

J Neurosci. 2011 Apr 20;31(16):6028-40. doi: 10.1523/JNEUROSCI.6069-10.2011.

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