研究業績｜筑波大学国際統合睡眠医科学研究機構櫻井/平野研究室

ORIGINAL RESEARCH

Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice

Tsuneki H, Tokai E, Nakamura Y, Takahashi K, Fujita M, Asaoka T, Kon K, Anzawa Y, Wada T, Takasaki I, Kimura K, Inoue H, Yanagisawa M, Sakurai T, Sasaoka T.

Diabetes. 2015 Feb;64(2):459-70. doi: 10.2337/db14-0695. Epub 2014 Sep 23.

ORIGINAL RESEARCH

OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

Thompson MD, Xhaard H, Sakurai T, Rainero I, Kukkonen JP.

Front Neurosci. 2014 May 6;8:57. doi: 10.3389/fnins.2014.00057. eCollection 2014.

ORIGINAL RESEARCH

Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function

Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A.

J Neurosci. 2014 May 7;34(19):6495-509. doi: 10.1523/JNEUROSCI.0073-14.2014.

ORIGINAL RESEARCH

Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons

Schöne C, Apergis-Schoute J, Sakurai T, Adamantidis A, Burdakov D.

Cell Rep. 2014 May 8;7(3):697-704. doi: 10.1016/j.celrep.2014.03.055. Epub 2014 Apr 24.

ORIGINAL RESEARCH

Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice

Etori K, Saito YC, Tsujino N, Sakurai T.

Front Neurosci. 2014 Jan 31;8:8. doi: 10.3389/fnins.2014.00008. eCollection 2014.

ORIGINAL RESEARCH

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

Hasegawa E, Yanagisawa M, Sakurai T, Mieda M.

J Clin Invest. 2014 Feb;124(2):604-16. doi: 10.1172/JCI71017. Epub 2014 Jan 2.

ORIGINAL RESEARCH

GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons

Saito YC, Tsujino N, Hasegawa E, Akashi K, Abe M, Mieda M, Sakimura K, Sakurai T.

Front Neural Circuits. 2013 Dec 2;7:192. doi: 10.3389/fncir.2013.00192. eCollection 2013.

ORIGINAL RESEARCH

Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation

Soya S, Shoji H, Hasegawa E, Hondo M, Miyakawa T, Yanagisawa M, Mieda M, Sakurai T.

J Neurosci. 2013 Sep 4;33(36):14549-57. doi: 10.1523/JNEUROSCI.1130-13.2013.

ORIGINAL RESEARCH

Orexin neurons are indispensable for prostaglandin E2-induced fever and defence against environmental cooling in mice

Takahashi Y, Zhang W, Sameshima K, Kuroki C, Matsumoto A, Sunanaga J, Kono Y, Sakurai T, Kanmura Y, Kuwaki T.

J Physiol. 2013 Nov 15;591(22):5623-43. doi: 10.1113/jphysiol.2013.261271. Epub 2013 Aug 19.

ORIGINAL RESEARCH

Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice

Tsujino N, Tsunematsu T, Uchigashima M, Konno K, Yamanaka A, Kobayashi K, Watanabe M, Koyama Y, Sakurai T.

PLoS One. 2013 Jul 29;8(7):e70012. doi: 10.1371/journal.pone.0070012. Print 2013.

ORIGINAL RESEARCH

Orexin-neuromodulated cerebellar circuit controls redistribution of arterial blood flows for defense behavior in rabbits

Nisimaru N, Mittal C, Shirai Y, Sooksawate T, Anandaraj P, Hashikawa T, Nagao S, Arata A, Sakurai T, Yamamoto M, Ito M.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14124-31. doi: 10.1073/pnas.1312804110. Epub 2013 Aug 2.

REVIEW

Differential roles of orexin receptors in the regulation of sleep/wakefulness

Mieda M, Tsujino N, Sakurai T.

Front Endocrinol (Lausanne). 2013 May 16;4:57. doi: 10.3389/fendo.2013.00057. eCollection 2013.

REVIEW

Orexin deficiency and narcolepsy

Sakurai T.

Curr Opin Neurobiol. 2013 Oct;23(5):760-6. doi: 10.1016/j.conb.2013.04.007. Epub 2013 May 7.

ORIGINAL RESEARCH

Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states

Furutani N, Hondo M, Kageyama H, Tsujino N, Mieda M, Yanagisawa M, Shioda S, Sakurai T.

PLoS One. 2013 Apr 19;8(4):e62391. doi: 10.1371/journal.pone.0062391. Print 2013.

REVIEW

Role of orexin in modulating arousal, feeding, and motivation

Tsujino N, Sakurai T.

Front Behav Neurosci. 2013 Apr 18;7:28. doi: 10.3389/fnbeh.2013.00028. eCollection 2013.

REVIEW

NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion

Sakurai T.

Front Endocrinol (Lausanne). 2013 Mar 18;4:23. doi: 10.3389/fendo.2013.00023. eCollection 2013.

ORIGINAL RESEARCH

Hypocretin/orexin neurons contribute to hippocampus-dependent social memory and synaptic plasticity in mice

Yang L, Zou B, Xiong X, Pascual C, Xie J, Malik A, Xie J, Sakurai T, Xie XS.

J Neurosci. 2013 Mar 20;33(12):5275-84. doi: 10.1523/JNEUROSCI.3200-12.2013.

ORIGINAL RESEARCH

Hypothalamic orexin prevents hepatic insulin resistance induced by social defeat stress in mice

Tsuneki H, Tokai E, Sugawara C, Wada T, Sakurai T, Sasaoka T.

Neuropeptides. 2013 Jun;47(3):213-9. doi: 10.1016/j.npep.2013.02.002. Epub 2013 Mar 16.

OTHERS

Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status

Mieda M, Sakurai T.

CNS Drugs. 2013 Feb;27(2):83-90. doi: 10.1007/s40263-012-0036-8.

ORIGINAL RESEARCH

Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation

Xiong X, White RE, Xu L, Yang L, Sun X, Zou B, Pascual C, Sakurai T, Giffard RG, Xie XS.

Stroke. 2013 Mar;44(3):764-70. doi: 10.1161/STROKEAHA.112.681700. Epub 2013 Jan 24.

PUBLICATIONS研究業績

Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice

OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function

Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons

Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons

Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation

Orexin neurons are indispensable for prostaglandin E2-induced fever and defence against environmental cooling in mice

Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice

Orexin-neuromodulated cerebellar circuit controls redistribution of arterial blood flows for defense behavior in rabbits

Differential roles of orexin receptors in the regulation of sleep/wakefulness

Orexin deficiency and narcolepsy

Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states

Role of orexin in modulating arousal, feeding, and motivation

NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion

Hypocretin/orexin neurons contribute to hippocampus-dependent social memory and synaptic plasticity in mice

Hypothalamic orexin prevents hepatic insulin resistance induced by social defeat stress in mice

Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status

Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation