PUBLICATIONS研究業績

Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice

Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.

Endocrinology. 2016 Jan;157(1):195-206. doi: 10.1210/en.2015-1488. Epub 2015 Oct 22.

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Hypocretin/orexin prevents recovery from sickness

Tanaka S, Toyoda H, Honda Y, Seki Y, Sakurai T, Honda K, Kodama T.

Biomed Rep. 2015 Sep;3(5):648-650. doi: 10.3892/br.2015.491. Epub 2015 Jul 17.

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Messenger RNA expression profile of sleep-related genes in peripheral blood cells in patients with chronic kidney disease

Kitajima S, Iwata Y, Furuichi K, Sagara A, Shinozaki Y, Toyama T, Sakai N, Shimizu M, Sakurai T, Kaneko S, Wada T.

Clin Exp Nephrol. 2016 Apr;20(2):218-25. doi: 10.1007/s10157-015-1150-y. Epub 2015 Sep 20.

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Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies

Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, Tagami M, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Ohi K, Hashimoto R, Tanisawa K, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Irukayama-Tomobe Y, Saito YC, Sakurai T, Hayashida M, Sugimura H, Ikeda K.

Mol Brain. 2015 Aug 20;8:50. doi: 10.1186/s13041-015-0142-x.

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[Roles of orexin and effects of orexin receptor antagonists]

Sakurai T.

Nihon Rinsho. 2015 Jun;73(6):1023-30.

Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm

Mieda M, Ono D, Hasegawa E, Okamoto H, Honma K, Honma S, Sakurai T.

Neuron. 2015 Mar 4;85(5):1103-16. doi: 10.1016/j.neuron.2015.02.005.

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The role of orexin in motivated behaviours

Sakurai T.

Nat Rev Neurosci. 2014 Nov;15(11):719-31. doi: 10.1038/nrn3837. Epub 2014 Oct 10.

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Roles of orexins in the regulation of body weight homeostasis

Sakurai T.

Obes Res Clin Pract. 2014 Sep-Oct;8(5):e414-20. doi: 10.1016/j.orcp.2013.12.001. Epub 2013 Dec 28.

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Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice

Tsuneki H, Tokai E, Nakamura Y, Takahashi K, Fujita M, Asaoka T, Kon K, Anzawa Y, Wada T, Takasaki I, Kimura K, Inoue H, Yanagisawa M, Sakurai T, Sasaoka T.

Diabetes. 2015 Feb;64(2):459-70. doi: 10.2337/db14-0695. Epub 2014 Sep 23.

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OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

Thompson MD, Xhaard H, Sakurai T, Rainero I, Kukkonen JP.

Front Neurosci. 2014 May 6;8:57. doi: 10.3389/fnins.2014.00057. eCollection 2014.

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Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function

Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A.

J Neurosci. 2014 May 7;34(19):6495-509. doi: 10.1523/JNEUROSCI.0073-14.2014.

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Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons

Schöne C, Apergis-Schoute J, Sakurai T, Adamantidis A, Burdakov D.

Cell Rep. 2014 May 8;7(3):697-704. doi: 10.1016/j.celrep.2014.03.055. Epub 2014 Apr 24.

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Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice

Etori K, Saito YC, Tsujino N, Sakurai T.

Front Neurosci. 2014 Jan 31;8:8. doi: 10.3389/fnins.2014.00008. eCollection 2014.

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Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

Hasegawa E, Yanagisawa M, Sakurai T, Mieda M.

J Clin Invest. 2014 Feb;124(2):604-16. doi: 10.1172/JCI71017. Epub 2014 Jan 2.

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GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons

Saito YC, Tsujino N, Hasegawa E, Akashi K, Abe M, Mieda M, Sakimura K, Sakurai T.

Front Neural Circuits. 2013 Dec 2;7:192. doi: 10.3389/fncir.2013.00192. eCollection 2013.

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Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation

Soya S, Shoji H, Hasegawa E, Hondo M, Miyakawa T, Yanagisawa M, Mieda M, Sakurai T.

J Neurosci. 2013 Sep 4;33(36):14549-57. doi: 10.1523/JNEUROSCI.1130-13.2013.

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Orexin neurons are indispensable for prostaglandin E2-induced fever and defence against environmental cooling in mice

Takahashi Y, Zhang W, Sameshima K, Kuroki C, Matsumoto A, Sunanaga J, Kono Y, Sakurai T, Kanmura Y, Kuwaki T.

J Physiol. 2013 Nov 15;591(22):5623-43. doi: 10.1113/jphysiol.2013.261271. Epub 2013 Aug 19.

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Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice

Tsujino N, Tsunematsu T, Uchigashima M, Konno K, Yamanaka A, Kobayashi K, Watanabe M, Koyama Y, Sakurai T.

PLoS One. 2013 Jul 29;8(7):e70012. doi: 10.1371/journal.pone.0070012. Print 2013.

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Orexin-neuromodulated cerebellar circuit controls redistribution of arterial blood flows for defense behavior in rabbits

Nisimaru N, Mittal C, Shirai Y, Sooksawate T, Anandaraj P, Hashikawa T, Nagao S, Arata A, Sakurai T, Yamamoto M, Ito M.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14124-31. doi: 10.1073/pnas.1312804110. Epub 2013 Aug 2.

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Differential roles of orexin receptors in the regulation of sleep/wakefulness

Mieda M, Tsujino N, Sakurai T.

Front Endocrinol (Lausanne). 2013 May 16;4:57. doi: 10.3389/fendo.2013.00057. eCollection 2013.

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