Takeshi Sakurai Lab. Molecular Behavioral Physiology, Faculty of Medicine

PUBLICATIONS研究業績

ORIGINAL RESEARCH

Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons

Saito YC, Maejima T, Nishitani M, Hasegawa E, Yanagawa Y, Mieda M, Sakurai T.

J Neurosci. 2018 Jul 11;38(28):6366-6378. doi: 10.1523/JNEUROSCI.2835-17.2018. Epub 2018 Jun 18.

VIEW MORE

ORIGINAL RESEARCH

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Wang Y, Cao L, Lee CY, Matsuo T, Wu K, Asher G, Tang L, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Chérasse Y, Zhou J, Li Y, Wang T, Zhan X, Miyoshi C, Irukayama Y, Cao J, Meeks JP, Gautron L, Wang Z, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H, Kobayakawa R, Kobayakawa K, Beutler B, Liu Q.

Nat Commun. 2018 May 23;9(1):2041. doi: 10.1038/s41467-018-04324-3.

VIEW MORE

ORIGINAL RESEARCH

Hypocretin/orexin deficiency decreases cocaine abuse liability

Steiner N, Rossetti C, Sakurai T, Yanagisawa M, de Lecea L, Magistretti PJ, Halfon O, Boutrel B.

Neuropharmacology. 2018 May 1;133:395-403. doi: 10.1016/j.neuropharm.2018.02.010. Epub 2018 Feb 15.

VIEW MORE

ORIGINAL RESEARCH

Hand-Foot Syndrome and Post-Progression Treatment Are the Good Predictors of Better Survival in Advanced Hepatocellular Carcinoma Treated with Sorafenib: A Multicenter Study

Ogawa C, Morita M, Omura A, Noda T, Kubo A, Matsunaka T, Tamaki H, Shibatoge M, Tsutsui A, Senoh T, Nagano T, Takaguchi K, Tani J, Morishita A, Yoneyama H, Masaki T, Moriya A, Ando M, Deguchi A, Kokudo Y, Minami Y, Ueshima K, Sakurai T, Nishida N, Kudo M.

Oncology. 2017;93 Suppl 1:113-119. doi: 10.1159/000481241. Epub 2017 Dec 20.

VIEW MORE

ORIGINAL RESEARCH

Orexin modulates behavioral fear expression through the locus coeruleus

Soya S, Takahashi TM, McHugh TJ, Maejima T, Herlitze S, Abe M, Sakimura K, Sakurai T.

Nat Commun. 2017 Nov 20;8(1):1606. doi: 10.1038/s41467-017-01782-z.

VIEW MORE

ORIGINAL RESEARCH

Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Thompson MD, Sakurai T, Rainero I, Maj MC, Kukkonen JP.

Pharmaceuticals (Basel). 2017 Oct 8;10(4):79. doi: 10.3390/ph10040079.

VIEW MORE

ORIGINAL RESEARCH

Excitation of GABAergic Neurons in the Bed Nucleus of the Stria Terminalis Triggers Immediate Transition from Non-Rapid Eye Movement Sleep to Wakefulness in Mice

Kodani S, Soya S, Sakurai T.

J Neurosci. 2017 Jul 26;37(30):7164-7176. doi: 10.1523/JNEUROSCI.0245-17.2017. Epub 2017 Jun 22.

VIEW MORE

ORIGINAL RESEARCH

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):5731-5736. doi: 10.1073/pnas.1700499114. Epub 2017 May 15.

VIEW MORE

ORIGINAL RESEARCH

Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity

Hasegawa E, Maejima T, Yoshida T, Masseck OA, Herlitze S, Yoshioka M, Sakurai T, Mieda M.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3526-E3535. doi: 10.1073/pnas.1614552114. Epub 2017 Apr 10.

VIEW MORE

ORIGINAL RESEARCH

Angiomatoid fibrous histiocytoma of the scalp mimicking cutaneous angiosarcoma in incisional biopsy containing CD31-positive histiocytes: A potential histopathological pitfall

Kanameishi S, Kaku Y, Goto K, Ishida Y, Endo Y, Dainichi T, Sakurai T, Kataoka T, Miyagawa-Hayashino A, Kabashima K.

J Dermatol. 2018 Feb;45(2):235-237. doi: 10.1111/1346-8138.13843. Epub 2017 Mar 31.

VIEW MORE

ORIGINAL RESEARCH

Fine-Tuning Circadian Rhythms: The Importance of Bmal1 Expression in the Ventral Forebrain

Mieda M, Hasegawa E, Kessaris N, Sakurai T.

Front Neurosci. 2017 Feb 9;11:55. doi: 10.3389/fnins.2017.00055. eCollection 2017.

VIEW MORE

ORIGINAL RESEARCH

Low-Grade Neuroendocrine Carcinoma of the Skin (Primary Cutaneous Carcinoid Tumor) as a Distinctive Entity of Cutaneous Neuroendocrine Tumors: A Clinicopathologic Study of 3 Cases With Literature Review

Goto K, Anan T, Nakatsuka T, Kaku Y, Sakurai T, Fukumoto T, Kimura T, Shibata A.

Am J Dermatopathol. 2017 Apr;39(4):250-258. doi: 10.1097/DAD.0000000000000657.

VIEW MORE

ORIGINAL RESEARCH

Odour-induced analgesia mediated by hypothalamic orexin neurons in mice

Tashiro S, Yamaguchi R, Ishikawa S, Sakurai T, Kajiya K, Kanmura Y, Kuwaki T, Kashiwadani H.

Sci Rep. 2016 Nov 15;6:37129. doi: 10.1038/srep37129.

VIEW MORE

ORIGINAL RESEARCH

QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior

Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T.

PLoS One. 2016 Nov 11;11(11):e0164716. doi: 10.1371/journal.pone.0164716. eCollection 2016.

VIEW MORE

ORIGINAL RESEARCH

Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice

Tsuneki H, Kon K, Ito H, Yamazaki M, Takahara S, Toyooka N, Ishii Y, Sasahara M, Wada T, Yanagisawa M, Sakurai T, Sasaoka T.

Endocrinology. 2016 Nov;157(11):4146-4157. doi: 10.1210/en.2016-1404. Epub 2016 Sep 15.

VIEW MORE

ORIGINAL RESEARCH

Manipulating the Cellular Circadian Period of Arginine Vasopressin Neurons Alters the Behavioral Circadian Period

Mieda M, Okamoto H, Sakurai T.

Curr Biol. 2016 Sep 26;26(18):2535-2542. doi: 10.1016/j.cub.2016.07.022. Epub 2016 Aug 25.

VIEW MORE

REVIEW

Sleep Control, GPCRs, and Glucose Metabolism

Tsuneki H, Sasaoka T, Sakurai T.

Trends Endocrinol Metab. 2016 Sep;27(9):633-642. doi: 10.1016/j.tem.2016.06.011. Epub 2016 Jul 22.

VIEW MORE

ORIGINAL RESEARCH

Mesolimbic neuropeptide W coordinates stress responses under novel environments

Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6023-8. doi: 10.1073/pnas.1518658113. Epub 2016 May 2.

VIEW MORE

ORIGINAL RESEARCH

Comprehensive Behavioral Analysis of Male Ox1r (-/-) Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior

Abbas MG, Shoji H, Soya S, Hondo M, Miyakawa T, Sakurai T.

Front Behav Neurosci. 2015 Dec 10;9:324. doi: 10.3389/fnbeh.2015.00324. eCollection 2015.

VIEW MORE

ORIGINAL RESEARCH

Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury

Ayuzawa N, Nagase M, Ueda K, Nishimoto M, Kawarazaki W, Marumo T, Aiba A, Sakurai T, Shindo T, Fujita T.

Hypertension. 2016 Jan;67(1):99-106. doi: 10.1161/HYPERTENSIONAHA.115.06054. Epub 2015 Nov 2.

VIEW MORE