PUBLICATIONS研究業績

QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior

Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T.

PLoS One. 2016 Nov 11;11(11):e0164716. doi: 10.1371/journal.pone.0164716. eCollection 2016.

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Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice

Tsuneki H, Kon K, Ito H, Yamazaki M, Takahara S, Toyooka N, Ishii Y, Sasahara M, Wada T, Yanagisawa M, Sakurai T, Sasaoka T.

Endocrinology. 2016 Nov;157(11):4146-4157. doi: 10.1210/en.2016-1404. Epub 2016 Sep 15.

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Manipulating the Cellular Circadian Period of Arginine Vasopressin Neurons Alters the Behavioral Circadian Period

Mieda M, Okamoto H, Sakurai T.

Curr Biol. 2016 Sep 26;26(18):2535-2542. doi: 10.1016/j.cub.2016.07.022. Epub 2016 Aug 25.

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Sleep Control, GPCRs, and Glucose Metabolism

Tsuneki H, Sasaoka T, Sakurai T.

Trends Endocrinol Metab. 2016 Sep;27(9):633-642. doi: 10.1016/j.tem.2016.06.011. Epub 2016 Jul 22.

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Mesolimbic neuropeptide W coordinates stress responses under novel environments

Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6023-8. doi: 10.1073/pnas.1518658113. Epub 2016 May 2.

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Comprehensive Behavioral Analysis of Male Ox1r (-/-) Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior

Abbas MG, Shoji H, Soya S, Hondo M, Miyakawa T, Sakurai T.

Front Behav Neurosci. 2015 Dec 10;9:324. doi: 10.3389/fnbeh.2015.00324. eCollection 2015.

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Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury

Ayuzawa N, Nagase M, Ueda K, Nishimoto M, Kawarazaki W, Marumo T, Aiba A, Sakurai T, Shindo T, Fujita T.

Hypertension. 2016 Jan;67(1):99-106. doi: 10.1161/HYPERTENSIONAHA.115.06054. Epub 2015 Nov 2.

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Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice

Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.

Endocrinology. 2016 Jan;157(1):195-206. doi: 10.1210/en.2015-1488. Epub 2015 Oct 22.

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Hypocretin/orexin prevents recovery from sickness

Tanaka S, Toyoda H, Honda Y, Seki Y, Sakurai T, Honda K, Kodama T.

Biomed Rep. 2015 Sep;3(5):648-650. doi: 10.3892/br.2015.491. Epub 2015 Jul 17.

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Messenger RNA expression profile of sleep-related genes in peripheral blood cells in patients with chronic kidney disease

Kitajima S, Iwata Y, Furuichi K, Sagara A, Shinozaki Y, Toyama T, Sakai N, Shimizu M, Sakurai T, Kaneko S, Wada T.

Clin Exp Nephrol. 2016 Apr;20(2):218-25. doi: 10.1007/s10157-015-1150-y. Epub 2015 Sep 20.

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Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies

Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, Tagami M, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Ohi K, Hashimoto R, Tanisawa K, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Irukayama-Tomobe Y, Saito YC, Sakurai T, Hayashida M, Sugimura H, Ikeda K.

Mol Brain. 2015 Aug 20;8:50. doi: 10.1186/s13041-015-0142-x.

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[Roles of orexin and effects of orexin receptor antagonists]

Sakurai T.

Nihon Rinsho. 2015 Jun;73(6):1023-30.

Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm

Mieda M, Ono D, Hasegawa E, Okamoto H, Honma K, Honma S, Sakurai T.

Neuron. 2015 Mar 4;85(5):1103-16. doi: 10.1016/j.neuron.2015.02.005.

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The role of orexin in motivated behaviours

Sakurai T.

Nat Rev Neurosci. 2014 Nov;15(11):719-31. doi: 10.1038/nrn3837. Epub 2014 Oct 10.

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Roles of orexins in the regulation of body weight homeostasis

Sakurai T.

Obes Res Clin Pract. 2014 Sep-Oct;8(5):e414-20. doi: 10.1016/j.orcp.2013.12.001. Epub 2013 Dec 28.

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Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice

Tsuneki H, Tokai E, Nakamura Y, Takahashi K, Fujita M, Asaoka T, Kon K, Anzawa Y, Wada T, Takasaki I, Kimura K, Inoue H, Yanagisawa M, Sakurai T, Sasaoka T.

Diabetes. 2015 Feb;64(2):459-70. doi: 10.2337/db14-0695. Epub 2014 Sep 23.

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OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

Thompson MD, Xhaard H, Sakurai T, Rainero I, Kukkonen JP.

Front Neurosci. 2014 May 6;8:57. doi: 10.3389/fnins.2014.00057. eCollection 2014.

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Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function

Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A.

J Neurosci. 2014 May 7;34(19):6495-509. doi: 10.1523/JNEUROSCI.0073-14.2014.

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Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons

Schöne C, Apergis-Schoute J, Sakurai T, Adamantidis A, Burdakov D.

Cell Rep. 2014 May 8;7(3):697-704. doi: 10.1016/j.celrep.2014.03.055. Epub 2014 Apr 24.

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Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice

Etori K, Saito YC, Tsujino N, Sakurai T.

Front Neurosci. 2014 Jan 31;8:8. doi: 10.3389/fnins.2014.00008. eCollection 2014.

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